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Arg-Gly-Asp-Ser

Catalog No. T10366 CAS 91037-65-9

Synonyms: Fibronectin tetrapeptide, RGDS peptide

Arg-Gly-Asp-Ser is an integrin-binding sequence that inhibits integrin receptor function. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, MMP-9, and iNOS.

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Arg-Gly-Asp-Ser, CAS 91037-65-9

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Storage & Solubility Information

Description	Arg-Gly-Asp-Ser is an integrin-binding sequence that inhibits integrin receptor function. It decreases systemic inflammation via inhibition of collagen-triggered activation of leukocytes and attenuates expression of inflammatory cytokines, MMP-9, and iNOS.
In vitro	The Arg-Gly-Asp-Ser-modified surface causes up-regulation of αvβ3 integrin. Attachment to the Arg-Gly-Asp-Ser-treated membrane completely abolishes apoptosis induced by staurosporine, the Ca2+·Pi ion pair, and sodium nitroprusside. Arg-Gly-Asp-Ser-dependent resistance to apoptosis is eliminated, when the activity of the phosphatidylinositol 3-kinase pathway is inhibited [1]. Arg-Gly-Asp-Ser interacts with survivin, as well as with procaspase-3, -8 and -9. Arg-Gly-Asp-Ser-peptide binding to survivin is found to be specific, at high affinity (Kd: 27.5 μM) and locates at the survivin C-terminus [4].
In vivo	Administering Arg-Gly-Asp-Ser at doses of 2.5 or 5 mg/kg, one hour before lipopolysaccharide (LPS), significantly inhibits LPS-induced matrix metallopeptidase-9 (MMP-9) activity in bronchoalveolar lavage (BAL) fluid four hours after LPS exposure. Similarly, Arg-Gly-Asp-Ser given intraperitoneally (i.p.) at doses of 1, 2.5, or 5 mg/kg, one hour before LPS, effectively suppressed the LPS-induced increases in tumor necrosis factor-alpha (TNF-α) and macrophage inflammatory protein (MIP)-2 levels in BAL fluid at the four-hour mark post-LPS [2]. Furthermore, the Arg-Gly-Asp-Ser peptide significantly lowers TNF-α and MIP-2 production and reduces myeloperoxidase (MPO) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activity [3].

Synonyms	Fibronectin tetrapeptide, RGDS peptide
Molecular Weight	433.42
Formula	C15H27N7O8
CAS No.	91037-65-9

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (126.90 mM)

H2O: 25 mg/mL (57.68 mM)

References and Literature

1. Grigoriou V, et al. Apoptosis and survival of osteoblast-like cells are regulated by surface attachment. J Biol Chem. 2005 Jan 21;280(3):1733-9. 2. Moon C, et al. Synthetic RGDS peptide attenuates lipopolysaccharide-induced pulmonary inflammation by inhibiting integrin signaled MAP kinase pathways. Respir Res. 2009 Mar 9;10:18. 3. Yin X, et al. Synthetic RGDS peptide attenuated lipopolysaccharide/D-galactosamine-induced fulminant hepatic failure in mice. J Gastroenterol Hepatol. 2014 Jun;29(6):1308-15. 4. Aguzzi MS, et al. Intracellular targets of RGDS peptide in melanoma cells. Mol Cancer. 2010 Apr 22;9:84.

Citations

1. Sun B, Wu H, Lu J, et al. Irisin reduces bone fracture by facilitating osteogenesis and antagonizing TGF-β/Smad signaling in a growing mouse model of osteogenesis imperfecta. Journal of Orthopaedic Translation. 2023, 38: 175-189.

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Keywords

Arg-Gly-Asp-Ser 91037-65-9 Others ArgGlyAspSer Fibronectin tetrapeptide RGDS peptide Arg Gly Asp Ser inhibitor inhibit

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