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Arg-Gly-Asp-Ser acetate

Catalog No. T10366L CAS T10366L

Synonyms: Arg-Gly-Asp-Ser acetate(91037-65-9 free base)

Arg-Gly-Asp-Ser acetate is an integrin binding sequence that directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1. Arg-Gly-Asp-Ser acetate inhibits integrin receptor function.

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Arg-Gly-Asp-Ser acetate Chemical Structure

Arg-Gly-Asp-Ser acetate, CAS T10366L

Pack Size	Availability	Price/USD
5 mg	In stock	$ 35.00
10 mg	In stock	$ 47.00
25 mg	In stock	$ 95.00
50 mg	In stock	$ 159.00
100 mg	In stock	$ 288.00
200 mg	In stock	$ 433.00

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Purity: 98.14%

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Description	Arg-Gly-Asp-Ser acetate is an integrin binding sequence that directly and specifically bind pro-caspase-8, pro-caspase-9 and pro-caspase-3, while it does not bind pro-caspase-1. Arg-Gly-Asp-Ser acetate inhibits integrin receptor function.
In vitro	The RGDS-modified surface caused up-regulation of alpha(v)beta(3) integrin. Attachment to the RGDS-treated membrane completely abolished apoptosis induced by staurosporine, the Ca(2+).P(i) ion pair, and sodium nitroprusside. When the activity of the phosphatidylinositol 3-kinase pathway was inhibited, RGDS-dependent resistance to apoptosis was eliminated. These results indicated that the binding of cells to RGDS abrogated apoptosis via the mitochondrial pathway and that the suppression of apoptosis was dependent on the activity of phosphatidylinositol 3-kinase. RGDS interacts with survivin, as well as with procaspase-3, -8 and -9. Survivin, a known cell-cycle and survival-regulator is highly expressed in melanoma cells. RGDS-peptide binding to survivin was found to be specific, at high affinity (Kd 27.5 muM) and located at the survivin C-terminus. RGDS-survivin interaction appeared to play a key role, since RGDS lost its anti-mitogenic effect in survivin-deprived cells with a specific siRNA.
In vivo	Saline or LPS (1.5 mg/kg) was administered i.t. with or without a single dose of RGDS (1, 2.5, or 5 mg/kg, i.p.), anti-alphav or anti-beta3 mAb (5 mg/kg, i.p.). Mice were sacrificed 4 or 24 h post-LPS.

Synonyms	Arg-Gly-Asp-Ser acetate(91037-65-9 free base)
Molecular Weight	493.47
Formula	C17H31N7O10
CAS No.	T10366L

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keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Slightly soluble

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library NO PAINS Compound Library ReFRAME Related Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Arg-Gly-Asp-Ser acetate T10366L Cytoskeletal Signaling Integrin Arg-Gly-Asp-Ser acetate(91037-65-9 free base) Arg Gly Asp Ser acetate Arg-Gly-Asp-Ser Acetate ArgGlyAspSer acetate inhibitor inhibit

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