Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 33.00 | |
10 mg | In stock | $ 54.00 | |
25 mg | In stock | $ 105.00 | |
50 mg | In stock | $ 163.00 | |
100 mg | In stock | $ 247.00 | |
200 mg | In stock | $ 368.00 | |
500 mg | In stock | $ 596.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 48.00 |
Description | Argatroban (MCI-9038), a specific thrombin inhibitor, which is a non-heparin anticoagulant, prevents the formation of thrombi. |
Targets&IC50 | Thrombin:5-39 nM(Ki) |
In vitro | In a rat distal cerebral artery occlusion model, administration of Argatroban at a dose of 0.3 mg/hour significantly reduced the number of microthrombi following artery occlusion. Argatroban treatment (at 0.1 and 0.3 mg/hour) notably reversed the decline in local cerebral blood flow in rats with distal cerebral artery occlusion. |
In vivo | Argatroban directly induces phenotypic transformation in vascular smooth muscle cells, upregulating the expression of myofilament-related proteins, PAI-1, and β-actin mRNA. In animal models with thrombosis rich in platelets and erythrocytes, Argatroban (ED50=125 μg/kg) demonstrates antithrombotic effects. It exhibits antithrombin activity across a range (Ki=5 nM-39 nM). |
Synonyms | MCI-9038, MD-805, Argipidine |
Molecular Weight | 508.63 |
Formula | C23H36N6O5S |
CAS No. | 74863-84-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 6 mg/mL (11.79 mM)
DMSO: 9 mg/mL (17.69 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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Argatroban 74863-84-6 Proteases/Proteasome Thrombin MCI9038 MD805 MCI-9038 MCI 9038 inhibit Inhibitor MD 805 MD-805 Argipidine inhibitor