Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Arhalofenate (JNJ 39659100) is a selective partial agonist of peroxisome proliferator-activated receptor PPARγ. It is used for the treatment of type 2 diabetes.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 133.00 | |
5 mg | In stock | $ 302.00 | |
10 mg | In stock | $ 453.00 | |
25 mg | In stock | $ 747.00 | |
50 mg | In stock | $ 1,050.00 | |
100 mg | In stock | $ 1,420.00 | |
500 mg | In stock | $ 2,830.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 348.00 |
Description | Arhalofenate (JNJ 39659100) is a selective partial agonist of peroxisome proliferator-activated receptor PPARγ. It is used for the treatment of type 2 diabetes. |
In vitro | Arhalofenate displays a dose-dependent activation of mouse GAL4-PPAR-γ (EC50s: appr 12 μM). Arhalofenate is a prodrug ester, that is rapidly and completely modified in vivo by non-specific serum esterases to the mature free acid form Arhalofenate (MBX 102) acid. [2]. |
In vivo | MBX-102 significantly reduces fasting blood glucose, confirming that Arhalofenate (MBX 102) is an efficacious antidiabetic agent. Arhalofenate (60 mg/kg) causes a dramatic decrease in plasma and also results in a dose-dependent, significant decrease in the insulin resistance indexinsulin levels[1]. Arhalofenate (100 mg/kg, p.o.) obviously increases the glucose infusion rate and decreases hepatic glucose output in the clamped state in Zucker Diabetic Fatty (ZDF) rats. Arhalofenate (100 mg/kg, p.o.) significantly reduces triglyceride, free fatty acid, and cholesterol levels in ZDF rats. Arhalofenate (100 mg/kg, p.o.) also significantly lowers fasting plasma insulin, and robustly decreases fasting plasma triglycerides after 32 days of treatment in Zucker Fatty (ZF) rats[2]. |
Synonyms | JNJ 39659100, MBX 102 |
Molecular Weight | 415.79 |
Formula | C19H17ClF3NO4 |
CAS No. | 24136-23-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 32.5 mg/mL (78.16 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Arhalofenate 24136-23-0 DNA Damage/DNA Repair Metabolism PPAR JNJ-39659100 JNJ 39659100 MBX-102 Inhibitor inhibit JNJ39659100 MBX102 Peroxisome proliferator-activated receptors MBX 102 inhibitor