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Arzoxifene hydrochloride

Catalog No. T10379 CAS 182133-27-3

Synonyms: SERM 3, LY 353381 HCl

Arzoxifene hydrochloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue.

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Arzoxifene hydrochloride Chemical Structure

Arzoxifene hydrochloride, CAS 182133-27-3

Pack Size	Availability	Price/USD
25 mg	8-10 weeks	$ 2,120.00
50 mg	8-10 weeks	$ 2,780.00
100 mg	8-10 weeks	$ 3,700.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Arzoxifene hydrochloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue.
In vitro	Arzoxifene inhibits cell growth as effectively as the antiestrogen tamoxifen. Arzoxifene exerts a statistically significant inhibition of pS2 and progesterone receptor B mRNA expression. A significant agonistic effect is observed in the antitrypsin mRNA expression. In contrast to estradiol and tamoxifen, arzoxifene does not upregulate cathepsin D mRNA and protein expression.
In vivo	Arzoxifene prevents the ovariectomy-induced increase in body weight and serum cholesterol levels of treated rats and lowers them to below sham levels in a dose-dependent manner, with maximum efficacy similar to estrogen or raloxifene. Arzoxifene prevents loss of bone due to ovariectomy with maximal efficacy observed at 0.1-1 mg/kg/day ( ED50: about 0.01 mg/kg). Arzoxifene antagonizes the estrogen-induced elevation in uterine weight down to vehicle-dosed control levels (ED50: 0.03 mg/kg/day).

Synonyms	SERM 3, LY 353381 HCl
Molecular Weight	512.06
Formula	C28H30ClNO4S
CAS No.	182133-27-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Suh N, et al. Arzoxifene, a new selective estrogen receptor modulator for chemoprevention of experimental breast cancer. Cancer Res. 2001 Dec 1;61(23):8412-5.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Arzoxifene hydrochloride 182133-27-3 Others SERM-3 SERM 3 LY 353381 HCl SERM3 Arzoxifene Hydrochloride inhibitor inhibit

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