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Atractylenolide II

Catalog No. T5S0168   CAS 73069-14-4
Synonyms: 2-Atractylenolide, Asterolide

1. Atractylenolide II (2-Atractylenolide) has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p38 activation , ERK and Akt inactivation, p53 dependent.

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Atractylenolide II Chemical Structure
Atractylenolide II, CAS 73069-14-4
Pack Size Availability Price/USD Quantity
20 mg In stock $ 140.00
1 mL * 10 mM (in DMSO) In stock $ 80.00
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Purity: 99.89%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 1. Atractylenolide II (2-Atractylenolide) has antimelanoma effect by inhibiting STAT3 signalling. 2. Atractylenolide II has cytotoxic/apoptotic effects may via p38 activation , ERK and Akt inactivation, p53 dependent.
Source
Synonyms 2-Atractylenolide, Asterolide
Molecular Weight 232.32
Formula C15H20O2
CAS No. 73069-14-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (215.22 mM)

TargetMolReferences and Literature

1. Fu X Q , Chou G X , Kwan H Y , et al. Inhibition of STAT3 signalling contributes to the antimelanoma action of atractylenolide II[J]. Experimental Dermatology, 2014, 23(11):855-857.

TargetMolCitations

1. Wang F, Li Z, Chen L, et al. Inhibition of ASCT2 induces hepatic stellate cell senescence with modified proinflammatory secretome through an IL-1α/NF-κB feedback pathway to inhibit liver fibrosis. Acta Pharmaceutica Sinica B. 2022 2. Cao L, Xu E, Zheng R, et al. Traditional Chinese medicine Lingguizhugan decoction ameliorate HFD-induced hepatic-lipid deposition in mice by inhibiting STING-mediated inflammation in macrophages. Chinese Medicine. 2022, 17(1): 1-16.

Related compound libraries

This product is contained In the following compound libraries:
JAK-STAT Compound Library Anti-Colorectal Cancer Compound Library Glutamine Metabolism Compound Library Glycolysis Compound Library Anti-Ovarian Cancer Compound Library HIF-1 Signaling Pathway Compound Library NO PAINS Compound Library RO5 Drug-like Natural Product Library Anti-Fibrosis Compound Library Terpene Natural Product Library

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Keywords

Atractylenolide II 73069-14-4 Apoptosis Cytoskeletal Signaling JAK/STAT signaling MAPK PI3K/Akt/mTOR signaling Stem Cells ERK p38 MAPK Akt STAT inhibit 2-Atractylenolide Asterolide Inhibitor inhibitor

 

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