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Aurantiamide acetate

Catalog No. TJS2216   CAS 56121-42-7
Synonyms: Asperglaucide

Aurantiamide acetate (Asperglaucide) was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally active cathepsin inhibitor. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases[1][2].

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Aurantiamide acetate Chemical Structure
Aurantiamide acetate, CAS 56121-42-7
Pack Size Availability Price/USD Quantity
1 mg In stock $ 123.00
5 mg In stock $ 263.00
10 mg In stock $ 393.00
25 mg In stock $ 646.00
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1 mL * 10 mM (in DMSO) In stock $ 288.00
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Purity: 99.68%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Aurantiamide acetate (Asperglaucide) was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate is a selective and orally active cathepsin inhibitor. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases[1][2].
Targets&IC50 Cathepsin B:49 μM, Cathepsin L:12 μM
In vitro Aurantiamide acetate decreases viability of U87 and U251 cancer cells in vitro when used at concentrations ranging from 10 to 100 μM. Aurantiamide acetate inhibited cysteine proteinases, in particular, cathepsin L and B with IC50 of 12 microM and 49 microM, respectively.
In vivo Aurantiamide acetate reduces tumor growth when administered at a dose of 1 mg via intratumoral injection in a U87 mouse xenograft model. In the adjuvant-arthritic rat model, subcutaneously administered 10 mg/kg body weight of this compound suppressed hind paw swelling.
Source
Synonyms Asperglaucide
Molecular Weight 444.52
Formula C27H28N2O4
CAS No. 56121-42-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (123.73 mM)

TargetMolReferences and Literature

1. K Isshiki, et al. Aurantiamide Acetate, a Selective Cathepsin Inhibitor, Produced by Aspergillus Penicilloides. Biosci Biotechnol Biochem. 2001 May;65(5):1195-7. 2. Chi-Su Yoon, et al. Anti-neuroinflammatory Effect of Aurantiamide Acetate From the Marine Fungus Aspergillus Sp. SF-5921: Inhibition of NF-κB and MAPK Pathways in Lipopolysaccharide-Induced Mouse BV2 Microglial Cells.Int Immunopharmacol. 2014 Dec;23(2):568-74.

Related compound libraries

This product is contained In the following compound libraries:
Miao medicine Compound Library Marine Natural Product Library Tobacco Monomer Library Alkaloid Natural Product Library Traditional Mongolian Medicine Compound Library Bioactive Compounds Library Max Anti-Tumor Natural Product Library Orally Active Compound Library RO5 Drug-like Natural Product Library Food as Medicine Compound Library

Related Products

Related compounds with same targets
MIV-247 Cathepsin Inhibitor 1 3,4 Dichloroisocoumarin Aureusimine B Acetyl-Calpastatin (184-210)(human) acetate ONO-5334 GLPG2451 KGP94

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Keywords

Aurantiamide acetate 56121-42-7 Proteases/Proteasome Cysteine Protease Inhibitor cathepsin L Piper aurantiacum Aurantiamide Acetate Asperglaucide adjuvant-arthritic Cathepsin inhibit Aurantiamide inflammatory diseases inhibitor

 

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