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Aurora Kinase Inhibitor III

Catalog No. T5524 CAS 879127-16-9

Aurora kinase inhibitor III is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR.

Aurora Kinase Inhibitor III, CAS 879127-16-9

Pack Size	Availability	Price/USD
1 mg	In Stock	86.00
5 mg	In Stock	200.00
25 mg	In Stock	620.00
1 mL * 10 mM (in DMSO)	In stock	200.00

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Purity 98.00%

HNMR COA Datasheet MSDS

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Aurora kinase inhibitor III is a potent inhibitor of Aurora A kinase (IC50 = 42 nM).1 It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR.
Targets&IC50	Aurora A :ic50 42 nM,

Molecular Weight	413.4
Formula	C21H18F3N5O
CAS No.	879127-16-9

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 50 mg/mL (120.9 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Zhang Q , Liu Y , Gao F , et al. Discovery of EGFR Selective 4,6-Disubstituted Pyrimidines from a Combinatorial Kinase-Directed Heterocycle Library[J]. Journal of the American Chemical Society, 2006, 128(7):2182-2183. 2. Tari L W , Hoffman I D , Bensen D C , et al. Structural basis for the inhibition of Aurora A kinase by a novel class of high affinity disubstituted pyrimidine inhibitors[J]. Bioorganic and Medicinal Chemistry Letters, 2007, 17(3):688-691.

Related Products

Related compounds with same targets

SP-146 Aurora Kinase Inhibitor III SNS-314 Mesylate Aurora inhibitor 1 SCH-1473759 AZD1152 MBM-17S MBM-17

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.