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Aurora inhibitor 1

Catalog No. T10412 CAS 2227019-45-4

Aurora inhibitor 1 is a potent Aurora inhibitor (IC50: ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase).

Aurora inhibitor 1, CAS 2227019-45-4

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Purity 98.00%

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Aurora inhibitor 1 is a potent Aurora inhibitor (IC50: ≤ 4 nM and ≤13 nM for Aurora A and Aurora B kinase).
Targets&IC50	Aurora A :ic50 4 nM, Aurora B :ic50 13 nM,
In vivo	In vivo efficacy in a mouse xenograft tumor model when dosed orally, Aurora inhibitor 1 exhibits good drug exposure levels across species upon oral dosing and shows excellent.

Molecular Weight	459.57
Formula	C23H25N9S
CAS No.	2227019-45-4

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Yu T, et al. Discovery of a highly potent orally bioavailable imidazo-[1, 2-a]pyrazine Aurora inhibitor. Bioorg Med Chem Lett. 2018 May 1;28(8):1397-1403.

Related Products

Related compounds with same targets

SP-146 Aurora Kinase Inhibitor III SNS-314 Mesylate Aurora inhibitor 1 SCH-1473759 AZD1152 MBM-17S MBM-17

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.