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Aurothiomalate sodium

Catalog No. T20168 CAS 12244-57-4

Synonyms: Myocrisin, Myocrisine, Miochrysin, Sodium aurothiomalate, Myochrysine, gold sodium thiomalate

Sodium aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Aurothiomalate sodium (Miochrysin) is a potent and selective inhibitor of oncogenic PKC-ι signaling. Aurothiomalate sodium is a potent thioredoxin reductase (TrxR) inhibitor. Aurothiomalate sodium exhibits potent anti-tumor activity.

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Aurothiomalate sodium Chemical Structure

Aurothiomalate sodium, CAS 12244-57-4

Pack Size	Availability	Price/USD
5 mg	In stock	$ 47.00
10 mg	In stock	$ 72.00
25 mg	In stock	$ 147.00
50 mg	In stock	$ 228.00
100 mg	In stock	$ 372.00
200 mg	In stock	$ 549.00

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Purity: 99.66%

Biological Description

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Description

Synonyms	Myocrisin, Myocrisine, Miochrysin, Sodium aurothiomalate, Myochrysine, gold sodium thiomalate
Molecular Weight	390.07
Formula	C4H3AuNa2O4S
CAS No.	12244-57-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 200 mg/mL

DMSO: Insoluble

References and Literature

1. Nummenmaa E, Hämäläinen M, Moilanen LJ, Moilanen T, Vuolteenaho K, Moilanen E. TRPA1 expression is downregulated by dexamethasone and aurothiomalate in human chondrocytes: TRPA1 as a novel factor and drug target in arthritis. RMD Open. 2017 Sep 4;3(2):e000556. 2. Darabi F, Marzo T, Massai L, Scaletti F, Michelucci E, Messori L. Reactions of model proteins with aurothiomalate, a clinically established gold(I) drug: The comparison with auranofin. J Inorg Biochem. 2015 Aug;149:102-7. 3. Tuure L, Hämäläinen M, Moilanen T, Moilanen E. Aurothiomalate inhibits the expression of mPGES-1 in primary human chondrocytes. Scand J Rheumatol. 2015;44(1):74-9. 4. Scharf VF, Farese JP, Siemann DW, Abbott JR, Kiupel M, Salute ME, Milner RJ. Effects of aurothiomalate treatment on canine osteosarcoma in a murine xenograft model. Anticancer Drugs. 2014 Mar;25(3):332-9.

Related compound libraries

This product is contained In the following compound libraries：

TGF-beta/Smad Compound Library Inhibitor Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Cytoskeletal Signaling Pathway Compound Library FDA-Approved & Pharmacopeia Drug Library Covalent Inhibitor Library Anti-Cancer Compound Library Approved Drug Library

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Keywords

Aurothiomalate sodium 12244-57-4 Chromatin/Epigenetic Cytoskeletal Signaling Others PKC NSCLC inhibit NF-kB A427 Aurothiomalate Erk SCLC Inhibitor H460 H1703 Myocrisin thioredoxin Mek A549 H1437 reductase anti-rheumatoid Myocrisine H510 LAC H187 Miochrysin TrxR Protein kinase C Sodium aurothiomalate LACs H2170 Myochrysine gold sodium thiomalate TNFa inhibitor

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