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Azathramycin

Catalog No. T3265 CAS 76801-85-9

Synonyms: Desmethyl Azithromycin, 6-Demethylazithromycin, Azaerythromycin A, Azaerythromycin

Azathramycin (Desmethyl Azithromycin) is an antibiotic derived from erythromycin, binding to the 50S subunit of the bacterial ribosome, and thus inhibits translation of mRNA.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Azathramycin, CAS 76801-85-9

Pack Size	Availability	Price/USD
50 mg	In stock	$ 41.00
100 mg	In stock	$ 57.00
200 mg	In stock	$ 86.00
500 mg	In stock	$ 148.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.43%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Azathramycin (Desmethyl Azithromycin) is an antibiotic derived from erythromycin, binding to the 50S subunit of the bacterial ribosome, and thus inhibits translation of mRNA.

Cell Research

THP-1 cells (106 cells in 1 mL RPMI medium, without antibiotics, growth factors or serum) are seeded in each well of 24-well plates and allowed to settle for 1 hour. Next, 50 μL of the test compound is added followed by 50 μL of LPS (final concentration of 10 μg/mL). After 24h (37°C and 5% CO2) the supernatants and cell pellets are collected (1200 rpm, 5 min). THP-1 cell viability is tested using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). MTT is dissolved at 2 mg/mL in PBS and aliquots are stored at -20°C. The MTT assay is performed according to the suppliers instructions. Absorbance of MTT converted into formazan is measured at a wavelength of 570 nm with background subtraction at 630 nm.

Synonyms	Desmethyl Azithromycin, 6-Demethylazithromycin, Azaerythromycin A, Azaerythromycin
Molecular Weight	734.96
Formula	C37H70N2O12
CAS No.	76801-85-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 7.35 mg/mL (10 mM)

References and Literature

1. Noedl H, et al. Antimicrob Agents Chemother. 2007 Feb;51(2):651-6.

Citations

1. Li H, Li J, Li J, et al.Carrimycin inhibits coronavirus replication by decreasing the efficiency of programmed–1 ribosomal frameshifting through directly binding to the RNA pseudoknot of viral frameshift-stimulatory element.Acta Pharmaceutica Sinica B.2024

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Bioactive Compounds Library Max FDA-Approved Drug Library Approved Drug Library Antibiotics Library Macrocyclic Compound Library Bioactive Compound Library Autophagy Compound Library Covalent Inhibitor Library Anti-Infection Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Azathramycin 76801-85-9 Microbiology/Virology Antibacterial Antibiotic Desmethyl Azithromycin Bacterial 6-Demethylazithromycin inhibit Azaerythromycin A Azaerythromycin Inhibitor inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.