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Azemiglitazone

Catalog No. T4639 CAS 1133819-87-0

Synonyms: MSDC 0602

Azemiglitazone (MSDC 0602) is an insulin sensitizer potentially for the treatment of diabetes.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Azemiglitazone, CAS 1133819-87-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 52.00
10 mg	In stock	$ 76.00
25 mg	In stock	$ 162.00
50 mg	In stock	$ 297.00
100 mg	In stock	$ 549.00
500 mg	In stock	$ 1,190.00
1 mL * 10 mM (in DMSO)	In stock	$ 58.00

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Purity: 99.6%

Purity: 97.02%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Azemiglitazone (MSDC 0602) is an insulin sensitizer potentially for the treatment of diabetes.

Synonyms	MSDC 0602
Molecular Weight	371.41
Formula	C19H17NO5S
CAS No.	1133819-87-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (336.56 mM), Sonification is recommended.

H2O: < 0.1 mg/mL (insoluble)

References and Literature

1. McCommis KS, Hodges WT, Brunt EM, Nalbantoglu I, McDonald WG, Holley C, Fujiwara H, Schaffer JE, Colca JR, Finck BN. Targeting the Mitochondrial Pyruvate Carrier Attenuates Fibrosis in a Mouse Model of Nonalcoholic Steatohepatitis. Hepatology. 2016 Dec 27. doi: 10.12002/hep.29025. 2. Fukunaga T, Zou W, Rohatgi N, Colca JR, Teitelbaum SL. An insulin-sensitizing thiazolidinedione, which minimally activates PPARγ, does not cause bone loss. J Bone Miner Res. 2015 Mar;30(3):481-8. 3. Chen Z, Vigueira PA, Chambers KT, Hall AM, Mitra MS, Qi N, McDonald WG, Colca JR, Kletzien RF, Finck BN. Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione. J Biol Chem. 2012 Jul 6;287(28):23537-48. 4. Colca, J., McDonald, W., Cavey, G., Cole, S., Holewa, D., & Brightwell-Conrad, A. et al. (2013). Identification of a Mitochondrial Target of Thiazolidinedione Insulin Sensitizers (mTOT)—Relationship to Newly Identified Mitochondrial Pyruvate Carrier Proteins. Plos ONE, 8(5), e61551. doi: 10.1371/journal.pone.0061551

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Kinase Inhibitor Library Drug Repurposing Compound Library Inhibitor Library Anti-Cancer Drug Library Anti-Aging Compound Library PI3K-AKT-mTOR Compound Library Anti-Colorectal Cancer Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max

Related Products

Related compounds with same targets

VK-28 CCI-006 Nerol Imeglimin hydrochloride CTPI-2 α-Lipoic Acid Lonidamine Olesoxime

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Azemiglitazone 1133819-87-0 Metabolism PI3K/Akt/mTOR signaling Mitochondrial Metabolism mTOR MSDC 0602 MSDC0602 MSDC-0602 inhibit Inhibitor inhibitor

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