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Azithromycin hydrate

Catalog No. T1419   CAS 117772-70-0
Synonyms: CP-62993 dihydrate, Azithromycin dihydrate

Azithromycin hydrate (CP-62993 dihydrate) is a semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.

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Azithromycin hydrate Chemical Structure
Azithromycin hydrate, CAS 117772-70-0
Pack Size Availability Price/USD Quantity
25 mg In stock $ 36.00
50 mg In stock $ 52.00
100 mg In stock $ 79.00
200 mg In stock $ 125.00
500 mg In stock $ 217.00
1 mL * 10 mM (in DMSO) In stock $ 39.00
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Purity: 99.9%
Purity: 99.83%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Azithromycin hydrate (CP-62993 dihydrate) is a semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.
In vivo Azithromycin (50 mg/kg) has no effect on bronchoalveolar lavage inflammatory parameters and LDH levels in a mouse model of asthma exacerbation. Azithromycin induces neither general inflammatory parameters nor LDH release in a mouse model of asthma exacerbation, and augments expression of interferon-stimulated genes and the pattern recognition receptor MDA5 which is sufficient to reduce viral load, but not RIG-I in exacerbating mice[2].
Cell Research THP-1 cells (106 cells in 1 mL RPMI medium, without antibiotics, growth factors or serum) are seeded in each well of 24-well plates and allowed to settle for 1 hour. Next, 50 μL of the test compound is added followed by 50 μL of LPS (final concentration of 10 μg/mL). After 24h (37°C and 5% CO2) the supernatants and cell pellets are collected (1200 rpm, 5 min). THP-1 cell viability is tested using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT). MTT is dissolved at 2 mg/mL in PBS and aliquots are stored at -20°C. The MTT assay is performed according to the suppliers instructions. Absorbance of MTT converted into formazan is measured at a wavelength of 570 nm with background subtraction at 630 nm.
Synonyms CP-62993 dihydrate, Azithromycin dihydrate
Molecular Weight 785.03
Formula C38H72N2O12·2H2O
CAS No. 117772-70-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 10 mg/mL (12.73 mM)

DMSO: 93 mg/mL (118.5 mM)

Ethanol: 93 mg/mL (118.5 mM)

TargetMolReferences and Literature

1. Peters DH, et al. Drugs, 1992, 44(5), 750-799. 2. Menzel M, et al. Azithromycin augments rhinovirus-induced IFNβ via cytosolic MDA5 in experimental models of asthma exacerbation. Oncotarget. 2017 Mar 18.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Microbial Natural Product Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Bioactive Compounds Library Max Anti-Infection Compound Library Saccharide and Glycoside Natural Product Library Antibiotics Library Covalent Inhibitor Library

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Keywords

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