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Azumolene

Catalog No. T8815 CAS 64748-79-4

Synonyms: EU4093 free base

Azumolene (EU4093 free base)

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Azumolene, CAS 64748-79-4

Pack Size	Availability	Price/USD
2 mg	In stock	$ 42.00
5 mg	In stock	$ 67.00
10 mg	In stock	$ 118.00
25 mg	In stock	$ 247.00
50 mg	In stock	$ 392.00
100 mg	In stock	$ 592.00
500 mg	In stock	$ 1,280.00
1 mL * 10 mM (in DMSO)	In stock	$ 75.00

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Purity: 98.59%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Azumolene (EU4093 free base)

In vivo

1.EU4093 (azumolene sodium) is a direct acting, skeletal muscle relaxant with structural similarities to dantrolene sodium in that the para-nitro phenyl group of dantrolene sodium is replaced by a para-bromo phenyl group.?2.?The effect of EU4093 on the twitch of the intact rat soleus preparation is nearly maximal at a dose of 20 mg kg-1.?This dose of EU4093 reduces the amplitude of the twitch to 31.9% of the control value.?By comparison, dantrolene sodium reduced the twitch amplitude to 31.3% of the control value at a dose of 5 mg kg-1.?3.?The contraction of intrafusal muscle as measured by the response of spindle afferent discharge was also reduced by EU4093.?4.?The most significant difference between the effect of EU4093 and dantrolene sodium on the contraction of intrafusal muscle was that EU4093 had an appreciable depressant action at high stimulation frequencies at which dantrolene sodium had only a minimal relaxant effect on the intrafusal muscle contraction.

Synonyms	EU4093 free base
Molecular Weight	349.14
Formula	C13H9BrN4O3
CAS No.	64748-79-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 13.89 mg/mL (39.78 mM), Sonification is recommended.

References and Literature

1. https://pubmed.ncbi.nlm.nih.gov/2790379/ 2. Viktor Yarotskyy, et al. Accelerated activation of SOCE current in myotubes from two mouse models of anesthetic- and heat-induced sudden death. PLoS One. 2013 Oct 15;8(10):e77633.

Related compound libraries

This product is contained In the following compound libraries：

Neuronal Signaling Compound Library Anti-Cardiovascular Disease Compound Library Bioactive Compounds Library Max Calcium Channel Compound Library ReFRAME Related Library Bioactive Compound Library Ion Channel Inhibitor Library Anti-Hypertension Compound Library Anti-Cancer Compound Library Metabolism Compound Library

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You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Azumolene 64748-79-4 Membrane transporter/Ion channel Metabolism Calcium Channel SOCE inhibit ryanodine EU-4093 Inhibitor Ca channels EU 4093 relaxant EU4093 free base Ca2+ channels muscle receptor calcium EU4093 inhibitor

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