Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC 50 s of 96 nM, 23 nM and 78 nM for hLH (human LH) and rLH (rat LH) and cLH (cynomolgus monkey LH), respectively. BAY-298 is the first nanomolar hLH-R antagonist reducing sex hormone levels in vivo[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | 8-10 weeks | $ 656.00 | |
25 mg | 8-10 weeks | $ 1,310.00 |
Description | BAY-298 is an orally active and selective luteinizing hormone receptor (LH-R) antagonist with IC 50 s of 96 nM, 23 nM and 78 nM for hLH (human LH) and rLH (rat LH) and cLH (cynomolgus monkey LH), respectively. BAY-298 is the first nanomolar hLH-R antagonist reducing sex hormone levels in vivo[1]. |
Targets&IC50 | LH (human):185 nM , LH (rat):46nM , LH (cynomolgus monkey):78 nM |
In vivo | BAY-298 administered orally at dosages ranging from 4.5 to 72 mg/kg/day over a period of 8 days, leads to a dose-dependent reduction in serum estradiol levels in proestrus in intact female rats. Additionally, when administered to female and male Wistar rats either intravenously (iv) at a dosage of 0.5 mg/kg or orally (po) at 2 mg/kg, BAY-298 exhibits half-lives of 31 hours and 33 hours, respectively, for iv and po routes. The maximum serum concentrations (Cmax) achieved are 0.28 kg/L for iv and 0.066 kg/L for po administration. |
Molecular Weight | 473.93 |
Formula | C27H21ClFN3O2 |
CAS No. | 2471978-97-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BAY-298 2471978-97-7 Others BAY 298 BAY298 inhibitor inhibit