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BCX 1470 methanesulfonate

Catalog No. T13567 CAS 217099-44-0

BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively.

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BCX 1470 methanesulfonate Chemical Structure

BCX 1470 methanesulfonate, CAS 217099-44-0

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,080.00
50 mg	6-8 weeks	$ 1,410.00
100 mg	6-8 weeks	$ 2,140.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), 3.4- and 200-fold better than that of trypsin, respectively.
Targets&IC50	Trypsin:326 nM , FD:96 nM , C1s:1.6 nM
In vitro	BCX 1470 methanesulfonate is an inhibitor serine protease. BCX 1470 blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro.
In vivo	BCX 1470 methanesulfonate blocked the development of RPA-induced edema in the rat.

Molecular Weight	398.48
Formula	C15H14N2O5S3
CAS No.	217099-44-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 33.33 mg/mL (83.64 mM)

References and Literature

1. Szalai, Alexander J.; Digerness, Stanley B.; et al.; The Arthus Reaction in Rodents: Species-Specific Requirement of ComplementJournal of Immunology, 2000, 164, 463-468 2. Szalai AJ, Digerness SB, Agrawal A, Kearney JF, Bucy RP, Niwas S, Kilpatrick JM, Babu YS, Volanakis JE.The Arthus reaction in rodents: species-specific requirement of complement.J Immunol. 2000 Jan 1;164(1):463-8.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BCX 1470 methanesulfonate 217099-44-0 Proteases/Proteasome Serine Protease inhibitor inhibit

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