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BEC HCl

Catalog No. T6779   CAS 222638-67-7
Synonyms: BEC hydrochloride
Purity 98.65% Datasheet

BEC HCl is a competitive arginase inhibitor,which bind slowly. Ki of BEC HCl is 0.31 μM (pH7.5) for Arginase II, and is 0.4-0.6 μM for rat Arginase I.

BEC HCl, CAS 222638-67-7
Pack Size Availability Price/USD Quantity
2 mg In stock 51.00
5 mg In stock 91.00
10 mg In stock 178.00
25 mg In stock 350.00
50 mg In stock 650.00
100 mg Inquiry 950.00
1 mL * 10 mM (in DMSO) In stock 91.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description BEC HCl is a competitive arginase inhibitor,which bind slowly. Ki of BEC HCl is 0.31 μM (pH7.5) for Arginase II, and is 0.4-0.6 μM for rat Arginase I.
Targets&IC50 Arginase-2 :ic50 0.31μM(Ki),   rat Arginase I :ic50 <0.6μM(Ki),  
In vitro BEC causes significant enhancement of NO-dependent smooth muscle relaxation. [2] In myocytes, BEC augments Ca(2+)-dependent NOS activity and NO production, and increases basal contractility. [3] BEC also inhibits the proliferation of human pulmonary artery smooth muscle cells by decreasing the expression levels of cyclin D1 and CDK4, increasing the expression of p27, and partly reducing the phosphorylation of Akt and ERK. [5]
Animal Research
Animal Model: Mice with allergic inflammation (OVA/OVA)
Synonyms BEC hydrochloride
Purity 98.65%
Appearance solid
Molecular Weight 229.49
Formula C5H12BNO4S·ClH
CAS No. 222638-67-7

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 42 mg/mL (183 mM)

Ethanol: 42 mg/mL (183 mM)

Water: 41 mg/mL (178.7 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Colleluori DM, et al. Biochemistry. 2001, 40(31), 9356-9362. 2. Kim NN, et al. Biochemistry. 2001, 40(9), 2678-2688. 3. Steppan J, et al. Proc Natl Acad Sci U S A. 2006, 103(12), 4759-4764. 4. Ckless K, et al. J Immunol. 2008, 181(6), 4255-4264. 5. Jiang W, et al. Mol Med Rep. 2015, 12(3), 4743-4749.

Related Compound Libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library

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nor-NOHA acetate Piceatannol 3'-O-glucoside Guanidine hydrochloride L-Ornithine Urea BEC HCl

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