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BIO-1211

Catalog No. T21868 CAS 187735-94-0

BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).

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BIO-1211, CAS 187735-94-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 113.00
2 mg	In stock	$ 168.00
5 mg	In stock	$ 289.00
10 mg	In stock	$ 463.00
25 mg	In stock	$ 748.00
50 mg	In stock	$ 987.00
100 mg	In stock	$ 1,380.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).
Targets&IC50	α4β7:2 μM, α4β1:4 nM
In vitro	BIO-1211 does not show activity against α1β1, α5β1, α6β1, αLβ2 and αIIbβ3[2].
In vivo	In naive, C57BL/6 mice, BIO-1211 exhibited a considerable depletion in the EAE clinical score, which correlated with decreased expression of TNF-α, IL-17, IFN-γ and pervade of CD11b+ and CD45+ cells into the cerebral cortex. BIO-1211 resulted in reduced cytokines expression, leukocyte trafficking, and inhibition of inflammatory responses in a dose-independent manner[1].

Molecular Weight	708.8
Formula	C36H48N6O9
CAS No.	187735-94-0

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (352.71 mM)

References and Literature

1. Nourollah Ramroodi, et al. Prophylactic Effect of BIO-1211 Small-Molecule Antagonist of VLA-4 in the EAE Mouse Model of Multiple Sclerosis. Immunol Invest. 2015;44(7):694-712. 2. K c Lin, et al. Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses. J Med Chem. 1999 Mar 11;42(5):920-34. 3. L L Chen, et al. Multiple activation states of integrin alpha4beta1 detected through their different affinities for a small molecule ligand. J Biol Chem. 1999 May 7;274(19):13167-75.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library Inhibitor Library Covalent Inhibitor Library Bioactive Compounds Library Max ReFRAME Related Library Cytoskeletal Signaling Pathway Compound Library Bioactive Compound Library Orally Active Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BIO-1211 187735-94-0 Cytoskeletal Signaling Integrin inhibit BIO1211 BIO 1211 Inhibitor inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.