keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor. With IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect[1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 51.00 | |
2 mg | In stock | $ 74.00 | |
5 mg | In stock | $ 122.00 | |
10 mg | In stock | $ 197.00 | |
25 mg | In stock | $ 389.00 | |
50 mg | In stock | $ 579.00 | |
100 mg | In stock | $ 828.00 | |
500 mg | In stock | $ 1,680.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 133.00 |
Description | BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor. With IC50s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect[1]. |
Targets&IC50 | GSK-3α:16 nM, GSK-3β:21 nM |
In vitro | BIP-135 (20 μM; 48 hours) is a superior neuroprotective agent in the model of oxidative stress[1]. BIP-135 (20-30 μM; 72 hours) increases the survival motor neuron (SMN) protein levels at a dose of 25 μM in human SMA fibroblasts. And the typical bell-shaped dose-response curve is observed due to some toxicity at higher concentrations[1]. |
In vivo | BIP-135 (75 mg/kg; i.p.; daily; from postnatal day 0 to 21) prolongs the median survival time of Δ7 SMA KO mouse model of spinal muscular atrophy. And it does not appear to be toxic and was well-tolerated by the animals (no decrease in body weight)[1]. |
Molecular Weight | 421.24 |
Formula | C21H13BrN2O3 |
CAS No. | 941575-71-9 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 56.7 mg/mL (134.6 mM), Sonification and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. More
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BIP-135 941575-71-9 PI3K/Akt/mTOR signaling Stem Cells GSK-3 BIP 135 BIP135 inhibitor inhibit