Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
5 mg | In stock | $ 77.00 | |
10 mg | In stock | $ 117.00 | |
25 mg | In stock | $ 213.00 | |
50 mg | In stock | $ 369.00 | |
100 mg | In stock | $ 549.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 88.00 |
Description | BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM). |
Targets&IC50 | RPS6KA6 (RSK4):990 nM, ERK5:59 nM, RPS6KA3 (RSK2):2.1 μM, Kit:1.1 μM, Abl1:2.4 μM, FGFR1:1 μM, CSF1R (FMS):46 nM, JAK3:440 nM, MEK5:1.5 nM, TGFβR1:580 nM, Lck:250 nM |
In vitro | BIX02189, which inhibited catalytic function of purified, MEK5 enzyme.?The MEK5 inhibitors blocked phosphorylation of ERK5, without affecting phosphorylation of ERK1/2 in sorbitol-stimulated HeLa cells.?The compounds also inhibited transcriptional activation of MEF2C, a downstream substrate of the MEK5/ERK5 signaling cascade, in a cellular trans-reporter assay system[1]. |
Synonyms | BIX 02189 |
Molecular Weight | 440.54 |
Formula | C27H28N4O2 |
CAS No. | 1265916-41-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 49.4 mg/mL (112.14 mM)
You can also refer to dose conversion for different animals. More
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BIX02189 1265916-41-3 MAPK ERK MEK Mitogen-activated protein kinase kinase inhibit MAP2K MAPKK BIX 02189 BIX-02189 Extracellular signal regulated kinases Inhibitor inhibitor