BMS202 hydrochloride (1675203-84-5(free base))

Catalog No. T4696 CAS T4696

Synonyms: PD-1/PD-L1 inhibitor 2 hydrochloride

Purity 99.47% Datasheet

PD-1/PD-L1 inhibitor 2 is a small-molecule PD-1/PD-L1 interaction inhibitor (IC50: 18 nM). Biophysical studies demonstrate that BMS202 binds directly to PD-L1. Binding of BMS202 promotes PD-L1 dimerisation and blocks the PD-L1/ PD1 interaction.

BMS202 hydrochloride (1675203-84-5(free base)), CAS T4696

Pack Size	Availability	Price/USD
1 mg	In stock	53.00
2 mg	In Stock	64.00
5 mg	In Stock	114.00
10 mg	In Stock	182.00
25 mg	In Stock	359.00
50 mg	In Stock	642.00
1 mL * 10 mM (in DMSO)	In stock	114.00

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Purity 99.47%

Datasheet

Biological Description

Chemical Properties

Storage & Solubility Information

Description	PD-1/PD-L1 inhibitor 2 is a small-molecule PD-1/PD-L1 interaction inhibitor (IC50: 18 nM). Biophysical studies demonstrate that BMS202 binds directly to PD-L1. Binding of BMS202 promotes PD-L1 dimerisation and blocks the PD-L1/ PD1 interaction.
Targets&IC50	PD-1/PD-L1 :ic50 18 nM,

Description

Targets&IC50

PD-1/PD-L1 :ic50 18 nM

Synonyms	PD-1/PD-L1 inhibitor 2 hydrochloride
Purity	99.47%
Appearance	solid
Molecular Weight	455.97
Formula	C25H30ClN3O3
CAS No.	T4696

Storage

-20℃ 3 years powder

-80℃ 2 years in solvent

Solubility Information

DMSO: 30 mg/mL(71.51 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Zak KM, Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1).Oncotarget. 2016 May 24;7(21):30323-35. 2. Pardoll DM.The blockade of immune checkpoints in cancer immunotherapy.Nat Rev Cancer. 2012 Mar 22;12(4):252-64.

Related Products

Related compounds with same targets

BMS202 hydrochloride (1675203-84-5(free base)) Phellodendrine chloride PD-1/PD-L1 inhibitor 1 Avelumab (anti- PD-L1) Atezolizumab (anti-PD-L1) BMS-1001 PD1-PDL1 inhibitor 2 Nivolumab (anti-PD-1)

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.