Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BPH-1358 (NSC50460) free base is a potent human undecaprenyl diphosphate synthase (UPPS) and farnesyl diphosphate synthase (FPPS) inhibitor (IC50s: 110 nM and 1.8 μM) and is active against S. aureus in vitro (MIC ~250 ng/mL).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | BPH-1358 (NSC50460) free base is a potent human undecaprenyl diphosphate synthase (UPPS) and farnesyl diphosphate synthase (FPPS) inhibitor (IC50s: 110 nM and 1.8 μM) and is active against S. aureus in vitro (MIC ~250 ng/mL). |
Targets&IC50 | Bisphosphonate farnesyl diphosphate synthase (human):1.8 μM |
In vitro | BPH-1358 is the most potent inhibitor of both E. coli UPPS (EcUPPS) and S. aureus UPPS (SaUPPS) (IC50: 110 nM). BPH-1358 against E. coli and S. aureus (EC50s: 300 nM and 290 nM) [1]. |
In vivo | In an i.p. infection model with an MRSA strain, BPH-1358 is active against S. aureus (20/20 mice survived) [1]. |
Synonyms | NSC50460 free base |
Molecular Weight | 528.6 |
Formula | C32H28N6O2 |
CAS No. | 801985-13-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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