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BT2

Catalog No. T14834   CAS 34576-94-8

BT2, a BCKDC kinase (BDK) inhibitor, exhibits an IC50 of 3.19 μM and functions as a potent, selective Mcl-1 inhibitor with a Ki value of 59 μM. Its interaction with BDK induces helix movements in the N-terminal domain, leading to BDK's dissociation from the branched-chain α-ketoacid dehydrogenase complex (BCKDC).

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BT2 Chemical Structure
BT2, CAS 34576-94-8
Pack Size Availability Price/USD Quantity
10 mg In stock $ 39.00
25 mg In stock $ 58.00
50 mg In stock $ 72.00
100 mg In stock $ 105.00
500 mg In stock $ 256.00
1 mL * 10 mM (in DMSO) In stock $ 38.00
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Purity: 99.86%
Purity: 99.77%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description BT2, a BCKDC kinase (BDK) inhibitor, exhibits an IC50 of 3.19 μM and functions as a potent, selective Mcl-1 inhibitor with a Ki value of 59 μM. Its interaction with BDK induces helix movements in the N-terminal domain, leading to BDK's dissociation from the branched-chain α-ketoacid dehydrogenase complex (BCKDC).
Targets&IC50 BDK:3.19 μM (IC50), MCL-1:59 μM (Ki)
In vivo BT2 treatment reduces the protein levels of BDK in kidneys and heart. The -fold activation of BCKDC activity in the above tissues correlates with decreased phosphorylation in heart, muscle, and kidney after the long term BT2 treatment. BT2 (20 mg/kg/day; i.p.; daily; for 7 days; C57BL/6J male mice) treatment robustly enhances BCKDC activity in the heart (12.3-fold) compared with the vehicle-treated animals. Less activation is obtained in muscle and kidney at 3.6- and 3.8-fold, respectively [1].
Molecular Weight 247.1
Formula C9H4Cl2O2S
CAS No. 34576-94-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 83.33 mg/mL (337.23 mM), sonification is recommended.

TargetMolReferences and Literature

1. Tso SC, et al. Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase. J Biol Chem. 2014 Jul 25;289(30):20583-93. 2. Friberg A, et al. Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. J Med Chem. 2013 Jan 10;56(1):15-30.

Related compound libraries

This product is contained In the following compound libraries:
Cuproptosis Compound Library Anti-Cancer Compound Library Kinase Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max Mitochondria-Targeted Compound Library Apoptosis Compound Library Inhibitor Library PPI Inhibitor Library NO PAINS Compound Library

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Keywords

BT2 34576-94-8 Apoptosis BCL Bcl-2 Family Inhibitor inhibit BT 2 BT-2 inhibitor

 

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