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Balixafortide TFA (1051366-32-5 free base)

Catalog No. TP2141 CAS TP2141

Synonyms: Balixafortide TFA, POL6326 TFA

Balixafortide TFA (POL6326 TFA) is a selective, well-tolerated peptidic CXCR4 antagonist (IC50 < 10 nM). It shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium flux (IC50s < 10 nM).

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Balixafortide TFA (1051366-32-5 free base) Chemical Structure

Balixafortide TFA (1051366-32-5 free base), CAS TP2141

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Balixafortide TFA (POL6326 TFA) is a selective, well-tolerated peptidic CXCR4 antagonist (IC50 < 10 nM). It shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium flux (IC50s < 10 nM).
Targets&IC50	CXCR4:10 nM
In vitro	Balixafortide efficiently blocks SDF-1 dependent chemotaxis of MDA MB 231 breast cancer cells (IC50 < 20 nM), Namalwa and Jurkat cells (IC50 < 10 nM). Balixafortide potently inhibits pERK / pAKT signaling in the lymphoma lines Jurkat (IC50 < 400 nM) and Namalwa (IC50< 200 nM) [1].
In vivo	Balixafortide is optimized for favorable mouse absorption, distribution, metabolism, and excretion (ADME) properties with balanced plasma protein binding, microsomal stability, and greater plasma.

Synonyms	Balixafortide TFA, POL6326 TFA
Molecular Weight	1896.05
Formula	C82H113N22F3O23S2
CAS No.	TP2141

Storage

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Zimmermann J, et al. Anti-tumor cell activity and in vitro profile of the next generation CXCR4 antagonist Balixafortide. Ann Oncol. 2018 Oct;29 Suppl 8:viii103. 2. Karpova D, et al. Mobilization of hematopoietic stem cells with the novel CXCR4 antagonist POL6326 (balixafortide) in healthy volunteers-results of a dose escalation trial. J Transl Med. 2017 Jan 3;15(1):2.

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Keywords

Balixafortide TFA (1051366-32-5 free base) TP2141 Autophagy GPCR/G Protein Immunology/Inflammation CXCR Balixafortide TFA 1051366-32-5 free base POL6326 TFA Balixafortide TFA (1051366 32 5 free base) 1051366-32-5 Balixafortide TFA (1051366325 free base) inhibitor inhibit

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