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Batatasin III

Catalog No. TN1433 CAS 56684-87-8

Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities. Batatasin III has a long-term inhibitory effect on whole-plant growth and shows germination

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Batatasin III, CAS 56684-87-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 179.00
2 mg	In stock	$ 269.00
5 mg	In stock	$ 455.00
10 mg	In stock	$ 672.00
25 mg	In stock	$ 1,060.00
50 mg	In stock	Inquiry

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Purity: 99.16%

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Description	Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities. Batatasin III has a long-term inhibitory effect on whole-plant growth and shows germination
In vivo	Batatasin III may impose a lethal effect on the aquatic fauna in small streams. The maximum concentration of Batatasin III found was 1.06 mg l(-1). The proportion of dead yolk sac alevins increased significantly (P < 0.001) with increasing concentrations of Batatasin III and time of exposure. After 24 hr, EC50 was 10 mg l(-1). It was 2 mg l(-1) after 48 hr. The effect of phenol was negligible, indicating a specific phytotoxic effect of the bibenzyl structure of Batatasin III. The proportion of mobile D. magna became significantly smaller (P < 0.001) with increasing concentrations of Batatasin III, with decreasing pH, and with increasing exposure time. EC50 varied between 7 and 17 mg l(-1) at pH 5.5 and 7.0, respectively. After 24 hr EC50 decreased and was 2.5 at pH 5.5 and 12 mg l(-1) at pH 7.0. The levels of Batatasin III found in the field samples were below the lowest EC50 in acute toxicity tests[1]. Batatasin III significantly suppresses mesenchymal transition indicated by the decrease of N-cadherin and Vimentin and up-regulation of E-cadherin[1]. Batatasin III (25-100 μM; 48 h) exhibits anti-proliferative activity in H460 cells. Batatasin III at concentrations lower than 100 μM has no cytotoxic effects[2].
Source	Natural Products > Orchidaceae > Dendrobium

Molecular Weight	244.29
Formula	C15H16O3
CAS No.	56684-87-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Potential toxic effect on aquatic fauna by the dwarf shrub Empetrum hermaphroditum.J Chem Ecol. 2004 Jan;30(1):215-27. 2. Tatchakorn Pinkhien, et al. Batatasin III Inhibits Migration of Human Lung Cancer Cells by Suppressing Epithelial to Mesenchymal Transition and FAK-AKT Signals. Anticancer Res. 2017 Nov;37(11):6281-6289.

Related compound libraries

This product is contained In the following compound libraries：

Rare Natural Compound Library RO5 Drug-like Natural Product Library

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Keywords

Batatasin III 56684-87-8 Angiogenesis Cytoskeletal Signaling Others PI3K/Akt/mTOR signaling Tyrosine Kinase/Adaptors Akt FAK Focal adhesion kinase Inhibitor inhibit PTK2 protein tyrosine kinase 2 PKB PTK2 Protein kinase B inhibitor

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