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Bax inhibitor peptide V5

Catalog No. T10463 CAS 579492-81-2

Synonyms: BIP-V5, BAX Inhibiting Peptide V5

Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor with anticancer activity.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Bax inhibitor peptide V5 Chemical Structure

Bax inhibitor peptide V5, CAS 579492-81-2

Pack Size	Availability	Price/USD
5 mg	5 days	$ 87.00
10 mg	5 days	$ 126.00
25 mg	5 days	$ 267.00
50 mg	5 days	$ 443.00
100 mg	5 days	Inquiry
200 mg	5 days	Inquiry

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Bax inhibitor peptide V5 (BIP-V5) is a Bax-mediated apoptosis inhibitor with anticancer activity.
In vitro	Bax inhibitor peptide V5 (0-50 μM) selectively reduces cell death in STF-cMyc cells, with no significant impact on NCI-H23 or SW620 cells. It does not notably affect cell cycle arrest at the G2/M phase [1]. Furthermore, the treatment with BIPV5 leads to a substantial increase in the expression of anti-apoptotic proteins Bcl-2 and XIAP, by over 3-fold and 11-fold respectively, while concurrently decreasing the expression of pro-apoptotic proteins Bax and Bad, and the nuclear factor-κB-p65, by 10%, 30%, and nearly 50% respectively [2].
In vivo	In mice model, Bax inhibitor peptide V5 (100 μM) significantly improves islet function following isolation and improves islet graft function following transplantation [2].

Synonyms	BIP-V5, BAX Inhibiting Peptide V5
Molecular Weight	586.79
Formula	C27H50N6O6S
CAS No.	579492-81-2

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (51.13 mM)

References and Literature

1. Jo MJ, et al. Regulation of cancer cell death by a novel compound, C604, in a c-Myc-overexpressing cellular environment. Eur J Pharmacol. 2015 Dec 15;769:257-65. 2. Rivas-Carrillo JD, et al. Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice. Diabetes. 2007 May;56(5):1259-67. Epub 2007 Feb 7.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bax inhibitor peptide V5 579492-81-2 Apoptosis BCL BIP-V5 Bax inhibitor peptide V-5 BAX Inhibiting Peptide V5 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.