store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bay 60-7550 is a selective and potent PDE2 inhibitor (Ki: 3.8 nM) that exerts positive inotropic effects on rat heart by increasing PKA-mediated phosphorylation and can be used to ameliorate cognitive impairments and memory disorders.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 97.00 | |
5 mg | In stock | $ 180.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 215.00 |
Description | Bay 60-7550 is a selective and potent PDE2 inhibitor (Ki: 3.8 nM) that exerts positive inotropic effects on rat heart by increasing PKA-mediated phosphorylation and can be used to ameliorate cognitive impairments and memory disorders. |
Targets&IC50 | PDE2:3.8±0.2 nM (Ki) |
In vitro | The anti-proliferative effect of BAY 60-7550 (1 μM) is pronounced, with a significant decrease in proliferation observed in PASMCs from IPAH patients compared to untreated control cells[2]. |
In vivo | Administration of the PDE2 inhibitors Bay 60-7550 (0.5, 1, and 3 mg/kg) or ND7001 (1 mg/kg), or the NO donor detanonoate (0.5 mg/kg), antagonized the anxiety-like behavior induced by restraint stress in mice [1]. |
Synonyms | BAY 607550 |
Molecular Weight | 476.57 |
Formula | C27H32N4O4 |
CAS No. | 439083-90-6 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (62.89 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Bay 60-7550 439083-90-6 Metabolism PDE BAY-607550 BAY607550 BAY 607550 Bay 60 7550 inhibitor inhibit