Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the HCV NS5B RNA-dependent RNA polymerase. It inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 (IC50 < 28 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | 10-14 weeks | $ 347.00 | |
25 mg | 10-14 weeks | $ 1,220.00 | |
50 mg | 10-14 weeks | $ 1,590.00 | |
100 mg | 10-14 weeks | $ 2,390.00 | |
1 mL * 10 mM (in DMSO) | 10-14 weeks | $ 517.00 |
Description | Beclabuvir is an allosteric inhibitor that binds to thumb site 1 of the HCV NS5B RNA-dependent RNA polymerase. It inhibits recombinant NS5B proteins from HCV genotypes 1, 3, 4, and 5 (IC50 < 28 nM). |
Targets&IC50 | NS5B protein:< 28 nM |
In vitro | Beclabuvir shows additive or synergistic antiviral activity with pegIFN/RBV and in 2- or 3-drug combinations with a range of DAAs, such as HCV NS5A inhibitors, NS3 protease inhibitors and/or nucleoside NS5B inhibitors [2]. |
In vivo | The combination of Beclabuvir with daclatasvir and asunaprevir achieves very high rates of viral eradication (about 90%) in patients infected with HCV genotype 1, which is the most common genotype worldwide [1]. |
Synonyms | BMS-791325 |
Molecular Weight | 659.84 |
Formula | C36H45N5O5S |
CAS No. | 958002-33-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (45.47 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Beclabuvir 958002-33-0 Others BMS791325 BMS-791325 BMS 791325 inhibitor inhibit