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Bemnifosbuvir

Catalog No. T9341 CAS 1998705-64-8

Synonyms: AT-511

Bemnifosbuvir (AT-511) is a novel phosphoramidate prodrug of 2'-fluoro-2'-C-methylguanosine-5'-monophosphate that has potent in vitro activity against HCV.

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Bemnifosbuvir, CAS 1998705-64-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 98.00
5 mg	In stock	$ 249.00
10 mg	In stock	$ 416.00
25 mg	In stock	$ 692.00
50 mg	In stock	$ 985.00
100 mg	In stock	$ 1,330.00
1 mL * 10 mM (in DMSO)	In stock	$ 525.00

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Purity: 99.69%

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Storage & Solubility Information

Description	Bemnifosbuvir (AT-511) is a novel phosphoramidate prodrug of 2'-fluoro-2'-C-methylguanosine-5'-monophosphate that has potent in vitro activity against HCV.
Targets&IC50	SARS-CoV-2:0.47 μM (EC90), HCV:5-28 nM (EC50)
In vitro	AT-511 is a novel phosphoramidate prodrug of 2'-fluoro-2'-C-methylguanosine-5'-monophosphate that has potent in vitro activity against HCV[1].In the absence of cells, AT-511 was stable when incubated in culture medium at 37°C for up to 24 h. AT-9010 was the predominant intracellular metabolite measured in all hepatocyte species and Huh-7 cell incubations with 10 μM AT-511 and, except in mouse hepatocytes,far exceeded intracellular AT-511 concentrations,demonstrating that the active TP was efficiently formed from its phosphoramidate protide in liver cells. In hepatocyte incubations, the relative levels of AT-9010 formed, and its accumulation over 24 h expressed as area under the curve or AUC0-24h; from most to least abundant, were rat>human >mouse >dog/monkey.
In vivo	Treatment with moxifloxacin every 8?hr was accompanied by longer survival than in any other group.Tissue cultures 30?hr after bacterial challenge showed considerably less bacterial growth in the spleens and lungs of moxifloxacin-treated animals than in the other groups, but not in their livers[2].

Synonyms	AT-511
Molecular Weight	581.53
Formula	C24H33FN7O7P
CAS No.	1998705-64-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (163.36 mM)

References and Literature

1. Steven S Good, et al. Preclinical evaluation of AT-527, a novel guanosine nucleotide prodrug with potent, pan-genotypic activity against hepatitis C virus. PLoS One. 2020 Jan 8;15(1):e0227104. 2. Ioannidis O, et al. Effect of moxifloxacin on survival, lipid peroxidation and inflammation in immunosuppressed rats with soft tissue infection caused by Stenotrophomonas maltophilia. Microbiol Immunol. 2014 Feb;58(2):96-102.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Bioactive Compound Library Anti-Viral Compound Library Nucleotide Compound Library Covalent Inhibitor Library Clinical Compound Library ReFRAME Related Library Anti-Infection Compound Library Bioactive Compounds Library Max

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Keywords

Bemnifosbuvir 1998705-64-8 Microbiology/Virology Others Proteases/Proteasome SARS-CoV HCV Protease guanosine pangenotypic Hepatitis C virus SARS coronavirus inhibit HCV Inhibitor antiviral AT511 AT 511 nucleotide AT-511 phosphoramidate inhibitor

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