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Benralizumab

Catalog No. T10497 CAS 1044511-01-4

Synonyms: BIW-8405, MEDI-563

Benralizumab (MEDI-563) is a monoclonal antibody targeting the interleukin-5 receptor alpha (IL-5Rα). It enhances antibody-dependent cell-mediated cytotoxicity, leading to a rapid depletion of eosinophils. Benralizumab is used for severe eosinophilic asthma and can be employed to prevent exacerbations of chronic obstructive pulmonary disease.

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Benralizumab, CAS 1044511-01-4

Pack Size	Availability	Price/USD
1 mg	In stock	$ 538.00
2 mg	In stock	$ 868.00
5 mg	In stock	$ 1,490.00
10 mg	In stock	$ 2,320.00
25 mg	In stock	$ 3,460.00

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Description	Benralizumab (MEDI-563) is a monoclonal antibody targeting the interleukin-5 receptor alpha (IL-5Rα). It enhances antibody-dependent cell-mediated cytotoxicity, leading to a rapid depletion of eosinophils. Benralizumab is used for severe eosinophilic asthma and can be employed to prevent exacerbations of chronic obstructive pulmonary disease.
Targets&IC50	Eosinophils (human):0.9 pM(EC50）, IL-5Rα:0.3nM, Basophils:0.5pM(EC50)
In vitro	The dissociation constants of the extracellular domain of recombinant human and cynomolgus IL-11Rα by Benralizumab ( MEDI-563 ) were 42 pM and 5 pM, respectively [ 2 ]. When inhibiting IL-5-induced proliferation of CTLL-48 cells transfected with recombinant human IL-2Rαβ ( 5 pM-1 nM, 100 hours ), the IC50 of benalizumab was 0.3 nM [ 2 ]. Benalizumab specifically binds to constructs containing human IL-5RαD1 and plays a role in mediating ADCC ( antibody-dependent cell-mediated cytotoxicity ) of human eosinophils and basophils, with EC50 values of 0.9 pM and 0.5 pM, respectively. In addition, it also promotes eosinophil apoptosis [ 2 ].
In vivo	Benalizumab ( MEDI-563 ) ( 0-30 mg / kg ; intravenous injection ; once every 3 weeks for 12 weeks ) can reduce peripheral blood and bone marrow eosinophils [ 2 ].

Synonyms	BIW-8405, MEDI-563
Molecular Weight	N/A
CAS No.	1044511-01-4

Storage

store at low temperature

store at -80°C

References and Literature

1. Menzies-Gow A, et al. Corticosteroid tapering with benralizumab treatment for eosinophilic asthma: PONENTE Trial. ERJ Open Res. 2019 Sep 25;5(3). pii: 00009-2019. 2. Kolbeck R, et al. MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function. J Allergy Clin Immunol. 2010 Jun;125(6):1344-1353.e2.

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Keywords

Benralizumab 1044511-01-4 Apoptosis Immunology/Inflammation IL Receptor Interleukin MEDI 563 BIW 8405 BIW-8405 MEDI-563 BIW8405 MEDI563 inhibitor inhibit

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