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Beta-Sheet Breaker Peptide iAβ5 Acetate

Catalog No. T21609L CAS T21609L

Synonyms: Beta-Sheet Breaker Peptide iAβ5 Acetate(182912-74-9 Free base)

Beta-Sheet Breaker Peptide iAβ5 Acetate (C33H43N5O8) inhibit amyloidogenesis in rat brain models.

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Beta-Sheet Breaker Peptide iAβ5 Acetate Chemical Structure

Beta-Sheet Breaker Peptide iAβ5 Acetate, CAS T21609L

Pack Size	Availability	Price/USD
5 mg	In stock	$ 53.00
10 mg	In stock	$ 74.00
25 mg	In stock	$ 97.00
50 mg	In stock	$ 157.00
100 mg	In stock	$ 236.00
200 mg	In stock	$ 353.00
500 mg	In stock	$ 531.00
1 mL * 10 mM (in DMSO)	In stock	$ 85.00

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Purity: 99.68%

Biological Description

Chemical Properties

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Description

Beta-Sheet Breaker Peptide iAβ5 Acetate (C33H43N5O8) inhibit amyloidogenesis in rat brain models.

In vivo

5-residue peptide that inhibits amyloid beta-protein fibrillogenesis, disassembles preformed fibrils in vitro and prevents neuronal death induced by fibrils in cell culture. In addition, the beta-sheet breaker peptide significantly reduces amyloid beta-protein deposition in vivo and completely blocks the formation of amyloid fibrils in a rat brain model of amyloidosis. These findings may provide the basis for a new therapeutic approach to prevent amyloidosis in Alzheimer's disease.

Synonyms	Beta-Sheet Breaker Peptide iAβ5 Acetate(182912-74-9 Free base)
Molecular Weight	697.78
Formula	C35H47N5O10
CAS No.	T21609L

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60mg/mL(94.08mM)

References and Literature

1. Soto C , Sigurdsson E M , Morelli L , et al. |[beta]|-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy[J]. Nature Medicine, 1998, 4(7):822-826.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library Bioactive Compound Library Bioactive Compounds Library Max NO PAINS Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

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