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Bezafibrate

Catalog No. T0841 CAS 41859-67-0

Synonyms: BM15075

Bezafibrate (BM15075) is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW-DENSITY LIPOPROTEINS and increases HIGH-DENSITY LIPOPROTEINS.

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Bezafibrate, CAS 41859-67-0

Pack Size	Availability	Price/USD
50 mg	In stock	$ 36.00
100 mg	In stock	$ 50.00
200 mg	In stock	$ 63.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.82%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Bezafibrate (BM15075) is an antilipemic agent that lowers CHOLESTEROL and TRIGLYCERIDES. It decreases LOW-DENSITY LIPOPROTEINS and increases HIGH-DENSITY LIPOPROTEINS.
Targets&IC50	PPARγ (human):60 μM, PPARα (human):50 μM, PPARγ (murine):55 μM, PPARδ (human):20 μM, PPARδ (murine):110 μM, PPARα (murine):90 μM
In vitro	Bezafibrate significantly decreases plasma triglyceride and leptin levels without altering the expression of PPARγ in white adipose tissue or the ob gene. Treatment with Bezafibrate resulted in much smaller gonadal fat stores in wild-type and PPARβ-null mice (2.8 and ~2.6 times less, respectively) than in controls, while PPARα-null mice did not exhibit this effect. Bezafibrate altered the expression of mRNAs coding for lipid metabolism enzymes, such as AOX, CYP4A, LPL, ACS, and LCAD, in wild-type, PPARβ-null, and PPARα-null mice. It induced the expression of UCPs in rat epididymal white adipose tissue and altered energy balance by directly inducing aco gene expression (14.5-fold increase on day 7) and peroxisomal fatty acid beta-oxidation. Bezafibrate treatment upregulated mRNA levels of M-CPT-I (4.5-fold), fatty acid translocase (2.6-fold), and Pref-1 (5.6-fold) in rat epididymal white adipose tissue. Compared to controls, Bezafibrate significantly increased liver weight in wild-type and PPARβ-null mice, with no change observed in PPARα-null mice.
In vivo	Bezafibrate exhibits an EC50 of 5 μM when binding to xPPARβ. Additionally, Bezafibrate activates the transcription of Xenopus PPARβ with an EC50 of 1 μM.

Synonyms	BM15075
Molecular Weight	361.82
Formula	C19H20ClNO4
CAS No.	41859-67-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 15 mg/mL (41.5 mM)

DMSO: 67 mg/mL (185.2 mM)

References and Literature

1. Krey G, et al. Mol Endocrinol, 1997, 11(6), 779-791. 2. Cabrero A, et al. Diabetes, 2001, 50(8), 1883-1890. 3. Peters JM, et al. Biochim Biophys Acta, 2003, 1632(1-3), 80-89. 4. Vázquez M, et al. Mol Cell Biochem. 2001 Jan;216(1-2):71-8. 6. Franko A, et al. Bezafibrate ameliorates diabetes via reduced steatosis and improved hepatic insulin sensitivity in diabetic TallyHo mice. Mol Metab. 2017 Jan 6;6(3):256-266. 7. Zeng X, Zhu S, Lu W, et al. Target identification among known drugs by deep learning from heterogeneous networks[J]. Chemical Science. 2020, 11(7): 1775-1797.

Citations

1. Zeng X, Zhu S, Lu W, et al. Target identification among known drugs by deep learning from heterogeneous networks. Chemical Science. 2020, 11(7): 1775-1797.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Cancer Drug Library Anti-Neurodegenerative Disease Compound Library Bioactive Lipid Compound Library Anti-Hypertension Compound Library Anti-Pancreatic Cancer Compound Library Approved Drug Library Anti-Alzheimer's Disease Compound Library

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Keywords

Bezafibrate 41859-67-0 DNA Damage/DNA Repair Metabolism PPAR inhibit BM15075 Peroxisome proliferator-activated receptors Inhibitor BM 15075 BM-15075 inhibitor

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