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Bimatoprost acid

Catalog No. T20939   CAS 38344-08-0
Synonyms: 17-phenyl trinor PGF2α, 17-phenyl trinor Prostaglandin F2α

Bimatoprost acid (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and has a potential antagonistic activity for the FP receptor. It has a relative potency of 756% compared to PGF2α for binding to the FP receptor on ovine luteal cells.

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Bimatoprost acid Chemical Structure
Bimatoprost acid, CAS 38344-08-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 156.00
5 mg In stock $ 320.00
10 mg In stock $ 475.00
25 mg In stock $ 779.00
50 mg In stock $ 1,090.00
100 mg In stock $ 1,470.00
1 mL * 10 mM (in DMSO) In stock $ 398.00
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Purity: 97.24%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Bimatoprost acid (17-phenyl trinor PGF2α) is a metabolically stable analog of PGF2α and has a potential antagonistic activity for the FP receptor. It has a relative potency of 756% compared to PGF2α for binding to the FP receptor on ovine luteal cells.
Synonyms 17-phenyl trinor PGF2α, 17-phenyl trinor Prostaglandin F2α
Molecular Weight 388.5
Formula C23H32O5
CAS No. 38344-08-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/ml (167.31 mM)

TargetMolReferences and Literature

1. 1.Yulia K , Kinuthia M W , Thoa T , et al. New Human Organotypic Corneal Tissue Model for Ophthalmic Drug Delivery Studies[J]. Investigative Ophthalmology & Visual Science, 2018, 59(7):2880-2898. 2. Klimko PG, Sharif NA. Discovery, characterization and clinical utility of prostaglandin agonists for the treatment of glaucoma. Br J Pharmacol. 2018 Apr 17. doi: 10.1111/bph.14327. [Epub ahead of print] Review. PubMed PMID: 29665040. 3. Shen J, Goodkin ML, Tong W, Attar M. Ocular pharmacokinetics and tolerability of bimatoprost ophthalmic solutions administered once or twice daily in rabbits, and clinical dosing implications. Clin Ophthalmol. 2017 Sep 28;11:1761-1767. doi: 10.2147/OPTH.S143428. eCollection 2017. Erratum in: Clin Ophthalmol. 2018 Aug 17;12:147PubMed PMID: 29026287; PubMed Central PMCID: PMC5627754. 4. Krupa M, Chodyński M, Ostaszewska A, Cmoch P, Dams I. A Novel Convergent Synthesis of the Potent Antiglaucoma Agent Tafluprost. Molecules. 2017 Jan 31;22(2). pii: E217. doi: 10.3390/molecules22020217. PubMed PMID: 28146132.

Related compound libraries

This product is contained In the following compound libraries:
Natural Product Library for HTS GPCR Compound Library RO5 Drug-like Natural Product Library NO PAINS Compound Library Endocrinology-Hormone Compound Library Bioactive Compound Library Inhibitor Library Natural Product Library Bioactive Compounds Library Max

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Keywords

Bimatoprost acid 38344-08-0 Endocrinology/Hormones GPCR/G Protein GPR 17-phenyl trinor PGF2α 17-phenyl trinor Prostaglandin F2a 17-phenyl trinor PGF2alpha 17-phenyl trinor Prostaglandin F2alpha 17-phenyl trinor Prostaglandin F2α 17-phenyl trinor PGF2a inhibitor inhibit

 

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