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Bis(maltolato)oxovanadium(IV)

Catalog No. T22276 CAS 38213-69-3

Synonyms: BMOV, Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium, Bis(maltolato)oxovanadium (IV)

Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases)inhibitor with insulin-mimicking effects and anti-diabetic properties. BMOV is a potent insulin sensitize. BMOV is shown to improve cardiac dysfunctions in diabetic models. BMOV inhibits HCPTPA, PTP1B, HPTPβ and SHP2 with IC50s of 126 nM, 109 nM, 26 nM and 201 nM, respectivelyr[1][2].

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Bis(maltolato)oxovanadium(IV) Chemical Structure

Bis(maltolato)oxovanadium(IV), CAS 38213-69-3

Pack Size	Availability	Price/USD
5 mg	In stock	$ 39.00
10 mg	In stock	$ 59.00
25 mg	In stock	$ 122.00
50 mg	In stock	$ 197.00
100 mg	In stock	$ 313.00
200 mg	In stock	$ 468.00
500 mg	In stock	$ 753.00
1 mL * 10 mM (in DMSO)	In stock	$ 43.00

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Purity: 99.10%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Bis(maltolato)oxovanadium(IV) (BMOV) is a potent, reversible, competitive and orally active pan-PTP (protein tyrosine phosphatases)inhibitor with insulin-mimicking effects and anti-diabetic properties. BMOV is a potent insulin sensitize. BMOV is shown to improve cardiac dysfunctions in diabetic models. BMOV inhibits HCPTPA, PTP1B, HPTPβ and SHP2 with IC50s of 126 nM, 109 nM, 26 nM and 201 nM, respectivelyr[1][2].
Targets&IC50	HCPTPA:126 nM (IC50), PTP1B:109 nM (IC50), HPTPβ:26 nM (IC50), SHP2:201 nM (IC50)
In vitro	BMOV treatment enhances the phosphorylation of the insulin receptor and of the insulin signalling key intermediate Akt. BMOV treatment also resultes in an increased glucose uptake in C2C12 cells[1].
In vivo	BMOV (0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; Male C57BL/6J mice) treatment ameliorates the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance.
Animal Research	BMOV (0.75-3.0 mmol; intraperitoneal injection; twice weekly; for 6 weeks; Male C57BL/6J mice) treatment ameliorates the metabolic phenotype, as evidenced by reduced body weight, improved insulin sensitivity and glucose tolerance.

Synonyms	BMOV, Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium, Bis(maltolato)oxovanadium (IV)
Molecular Weight	317.15
Formula	C12H10O7V
CAS No.	38213-69-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20 mg/mL (63.06 mM)

References and Literature

1. Janine Krüger, et al. Inhibition of Src homology 2 domain-containing phosphatase 1 increases insulin sensitivity in high-fat diet-induced insulin-resistant mice. FEBS Open Bio. 2016 Jan 4;6(3):179-89. 2. Kevin G Peters, et al. Mechanism of insulin sensitization by BMOV (bis maltolato oxo vanadium); unliganded vanadium (VO4) as the active component. J Inorg Biochem. 2003 Aug 1;96(2-3):321-30. 3. Cong XQ, et al. Biol Trace Elem Res. 2016 Oct;173(2):390-8.

Citations

1. Qiu X, Hou X, Yang Y, et al.An in-line method for high-throughput screening of protein tyrosine phosphatase receptor type O inhibitors by capillary electrophoresis based on electrophoretically mediated microanalysis.Journal of Chromatography A.2023: 464511.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Phosphatase Inhibitor Library Metabolism Compound Library Orally Active Compound Library Bioactive Compounds Library Max Glycometabolism Compound Library ReFRAME Related Library NO PAINS Compound Library Bioactive Compound Library

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Keywords

Bis(maltolato)oxovanadium(IV) 38213-69-3 Metabolism Others Phosphatase type-2 inhibit SHP2 Inhibitor BMOV phenotype metabolic Bis(maltolato)oxovanadium SHP-1 HCPTPA uptake glucose HPTPβ Bis maltolato oxovanadium,Bis(maltolato)oxovanadium (IV),bis maltolato oxo vanadium insulin Bis(maltolato)oxovanadium (IV) PTP PTP1B diabetes inhibitor

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