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Bisdemethoxycurcumin

Catalog No. TL0007 CAS 24939-16-0

Synonyms: Curcumin III, Didemethoxycurcumin

Bisdemethoxycurcumin (Curcumin III) is a natural demethoxy derivative of curcumin. It is a potent activator of macrophage phagocytosis, interacting with 1α, 25-dihydroxy vitamin D3 to stimulate amyloid-β clearance by macrophages (optimal stimulation at 100 nM BDMC) [1]. More stable than curcumin in physiological media, BDMC suppresses proliferation of cancer cells [2]. It down-regulates the transcriptional coactivator p300, suppressing the Wnt/β-catenin pathway, and inhibits LPS induction of iNOS expression [3].

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Bisdemethoxycurcumin, CAS 24939-16-0

Pack Size	Availability	Price/USD
5 mg	In stock	$ 41.00
50 mg	In stock	$ 135.00
100 mg	In stock	$ 203.00
1 mL * 10 mM (in DMSO)	In stock	$ 45.00

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Purity: 99.34%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Source

Natural Products > Zingiberaceae > Curcuma

Synonyms	Curcumin III, Didemethoxycurcumin
Molecular Weight	308.33
Formula	C19H16O4
CAS No.	24939-16-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mg/mL

Ethanol: 5 mg/mL

References and Literature

1. Fiala, M., Liu, P.T., Espinosa-Jeffrey, A., et al. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer’s disease patients are improved by bisdemethoxycurcumin. Proceedings of the National Academy of Sciences of the United States of America 104(31), 12849-12854 (2007). 2. Sandur, S.K., et al. Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism. Carcinogenesis 28(8), 1765-1773 (2007). 3. Ryu, M.J., et al. Natural derivatives of curcumin attenuate the Wnt/β-catenin pathway through down-regulation of the transcriptional coactivator p300. Biochemical and Biophysical Research Communications 377(4), 1304-1308 (2008).

Related compound libraries

This product is contained In the following compound libraries：

Neural Regeneration Compound Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Human Metabolite Library Traditional Chinese Medicine Monomer Library PBCRBS Traditional Chinese Medicine Compound Library Reprogramming Compound Library Anti-Ovarian Cancer Compound Library Wnt/Hedgehog/Notch Compound Library Selected Plant-Sourced Compound Library Histone Modification Compound Library

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Keywords

Bisdemethoxycurcumin 24939-16-0 Chromatin/Epigenetic Cytoskeletal Signaling Stem Cells Wnt/beta-catenin Epigenetic Reader Domain inhibit Inhibitor antiinflammatory curcuminoid antioxidant Curcumin III Bisdemethoxycucurmin Didemethoxycurcumin inhibitor

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