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Bisindolylmaleimide V

Catalog No. T7790 CAS 113963-68-1

Bisindolylmaleimide V, a bisindolylmaleimide derivative, is an inactive of a kinase inhibitor.

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Bisindolylmaleimide V, CAS 113963-68-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Bisindolylmaleimide V, a bisindolylmaleimide derivative, is an inactive of a kinase inhibitor.
Targets&IC50	S6K:8 μM
In vitro	Bisindolylmaleimide V(BIM V) blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 value of 8 μM

Molecular Weight	341.36
Formula	C21H15N3O2
CAS No.	113963-68-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: soluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Marmy-Conus N , Hannan K M , Pearson R B . Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70s6k/p85s6k: implications for the analysis of S6K signalling[J]. Febs Letters, 2002, 519(1-3):0-140. 2. Lazareno S , Popham A , Birdsall N J M . Muscarinic interactions of bisindolylmaleimide analogues[J]. European Journal of Pharmacology, 1998, 360(2-3):281-284.

Dose Conversion

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bisindolylmaleimide V 113963-68-1 Chromatin/Epigenetic Cytoskeletal Signaling MAPK PI3K/Akt/mTOR signaling PKC S6 Kinase inhibit Ribosomal S6 Kinase (RSK) Inhibitor BIM V S6K inhibitor

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