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Bisindolylmaleimide V

Catalog No. T7790 CAS 113963-68-1

Synonyms: 双吲哚马来酰亚胺 V, 双吲哚马来酰亚胺

Bisindolylmaleimide V, a bisindolylmaleimide derivative, is an inactive of a kinase inhibitor.

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Bisindolylmaleimide V, CAS 113963-68-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Bisindolylmaleimide V, a bisindolylmaleimide derivative, is an inactive of a kinase inhibitor.
Targets&IC50	S6K:8 μM
In vitro	Bisindolylmaleimide V(BIM V) blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) in vivo with an IC50 value of 8 μM

Synonyms	双吲哚马来酰亚胺 V, 双吲哚马来酰亚胺
Molecular Weight	341.37
Formula	C21H15N3O2
CAS No.	113963-68-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: soluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Marmy-Conus N , Hannan K M , Pearson R B . Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70s6k/p85s6k: implications for the analysis of S6K signalling[J]. Febs Letters, 2002, 519(1-3):0-140. 2. Lazareno S , Popham A , Birdsall N J M . Muscarinic interactions of bisindolylmaleimide analogues[J]. European Journal of Pharmacology, 1998, 360(2-3):281-284.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bisindolylmaleimide V 113963-68-1 MAPK信号通路 PI3K/Akt/mTOR信号通路表观遗传细胞骨架 PKC S6 Kinase inhibit Ribosomal S6 Kinase (RSK) Inhibitor BIM V S6K inhibitor

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