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Microbiology/Virology Antifection Brevilin A

Brevilin A

Catalog No. T4672   CAS 16503-32-5

Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 µM) in Cancer Cells.Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.antitumour

Brevilin A, CAS 16503-32-5
Pack Size Availability Price/USD Quantity
1 mg In stock 193.00
5 mg In stock 394.00
10 mg In stock 673.00
25 mg In stock 1211.00
1 mL * 10 mM (in DMSO) In stock 404.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Brevilin A is a sesquiterpene lactone isolated from Centipeda minima, inhibits janus kinase activity and blocks STAT3 signaling in cancer cells with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 µM) in Cancer Cells.Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.antitumour
Targets&IC50 Antifection,   JAK,   STAT,  
In vivo
Molecular Weight 346.41
Formula C20H26O5
CAS No. 16503-32-5

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 100 mg/mL (288.67 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Antiprotozoal activities of Centipeda minima. Phytother. Res., 1994, 8(8):436-8.

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