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Bromoenol lactone

Catalog No. T14829 CAS 88070-98-8

Synonyms: (6E)-Bromoenol lactone

Bromoenol lactone is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β; IC50: ~7 μM). It inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx.

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Bromoenol lactone, CAS 88070-98-8

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1 mL * 10 mM (in DMSO)	5 days	$ 162.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Bromoenol lactone is a suicide-based irreversible, selective, potent inhibitor of calcium-independent phospholipase A2 (iPLA2β; IC50: ~7 μM). It inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx.
Targets&IC50	PLA2:7 μM
In vitro	Bromoenol lactone inhibits exocytosis when stimulated using a Ca2+ ionophore A23187, which passively transports Ca2+ down a concentration gradient and also in permeabilized mast cells where Ca2+ entry is no longer relevant. In RBL 2H3 and bone marrow-derived mast cells (BMMCs), Ca2+ entry is critical for exocytosis. Moreover, Bromoenol lactone has only a minor effect on antigen- or thapsigargin-stimulated Ca2+ signaling, both the release from internal stores and sustained elevation due to Ca2+ influx [1].

Synonyms	(6E)-Bromoenol lactone
Molecular Weight	317.18
Formula	C16H13BrO2
CAS No.	88070-98-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Fensome-Green A, et al. Bromoenol lactone, an inhibitor of Group V1A calcium-independent phospholipase A2 inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx. Cell Calcium. 2007 Feb;41(2):145-53. 2. Takuma T, et al. Role of Ca2+-independent phospholipase A2 in exocytosis of amylase from parotid acinar cells. J Biochem. 1997 Jun;121(6):1018-24.

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Keywords

Bromoenol lactone 88070-98-8 Metabolism Phospholipase (6E)-Bromoenol lactone inhibitor inhibit

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