Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bufarenogin (3beta,12beta,14-Trihydroxy-11-oxo-5beta-bufa-20,22-dienolide) is a bufadienolide isolated from parotoid gland secretions of the Cuban endemic toad Peltophryne fustiger. Bufarenogin shows anti-tumor activity.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 72.00 | |
2 mg | In stock | $ 97.00 | |
5 mg | In stock | $ 189.00 | |
10 mg | In stock | $ 297.00 | |
25 mg | In stock | $ 513.00 | |
50 mg | In stock | Inquiry | |
1 mL * 10 mM (in DMSO) | In stock | $ 213.00 |
Description | Bufarenogin (3beta,12beta,14-Trihydroxy-11-oxo-5beta-bufa-20,22-dienolide) is a bufadienolide isolated from parotoid gland secretions of the Cuban endemic toad Peltophryne fustiger. Bufarenogin shows anti-tumor activity. |
In vitro | Bufarenogin caused cell death via apoptosis. Bufarenogin induced B-cell lymphoma 2-associated X protein (Bax)-dependent intrinsic apoptosis, as demonstrated by mitochondrial translocation of Bax and cytoplasm release of HCT116 wild-type cells and cytochrome C. Bufarenogin induced intrinsic apoptosis through the cooperation of Bax and adenine-nucleotide translocator and inhibited the metastasis and growth of orthotopical CRC cells[2]. |
Synonyms | 3beta,12beta,14-Trihydroxy-11-oxo-5beta-bufa-20,22-dienolide |
Molecular Weight | 416.51 |
Formula | C24H32O6 |
CAS No. | 17008-65-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (120.05 mM)
You can also refer to dose conversion for different animals. More
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Bufarenogin 17008-65-0 MAPK PI3K/Akt/mTOR signaling MEK PI3K ERK 3beta,12beta,14-Trihydroxy-11-oxo-5beta-bufa-20,22-dienolide inhibitor inhibit