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Buformin hydrochloride

Catalog No. T20029 CAS 1190-53-0

Synonyms: NSC528218, NSC-528218, NSC 528218

Buformin hydrochloride (NSC-528218) is a potent AMPK activator,an oral antidiabetic drug of the biguanide class. Buformin delays the absorption of glucose from the gastrointestinal tract increases insulin sensitivity and glucose uptake into cells and inhibits synthesis of glucose by the liver. Biguanides may antagonize the action of glucagon, thus reducing fasting glucose levels.

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Buformin hydrochloride Chemical Structure

Buformin hydrochloride, CAS 1190-53-0

Pack Size	Availability	Price/USD
10 mg	In stock	$ 30.00
25 mg	In stock	$ 44.00
50 mg	In stock	$ 64.00
100 mg	In stock	$ 97.00
200 mg	In stock	$ 158.00
500 mg	In stock	$ 297.00
1 mL * 10 mM (in DMSO)	In stock	$ 39.00

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Purity: 97.83%

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Storage & Solubility Information

Description	Buformin hydrochloride (NSC-528218) is a potent AMPK activator,an oral antidiabetic drug of the biguanide class. Buformin delays the absorption of glucose from the gastrointestinal tract increases insulin sensitivity and glucose uptake into cells and inhibits synthesis of glucose by the liver. Biguanides may antagonize the action of glucagon, thus reducing fasting glucose levels.
In vitro	Buformin hydrochloride (0-10 mM; 5 days) inhibits SKBR3 and BT474 cells growth as a concentration-dependent manner, exhibits IC50 values of 246.7 μM and ?98.6 μM for erbB-2-overexpressing SKBR3 and BT474 cells, respectively[1]. Buformin hydrochloride (0-3 mM; 48 hours) increases the percentage of cells in G0/G1 phase and reduced the percentage of cells in S phase, especially in the SKBR3 cells[1]. Buformin hydrochloride (0-3 mM; 24 hours) suppresses RTK activation, including erbB-2 and IGF1R signaling downstream, and Akt activation/phosphorylation is inhibited in both SKBR3 and BT474 cells[1].
In vivo	Buformin hydrochloride (oral administation; 7.6?mmol/kg of chow; 7 days) exhibits significantly reduced tumor volumes and weights, and?hinders mammary morphogenesis and proliferation in MMTV-erbB-2 transgenic mice[1].

Synonyms	NSC528218, NSC-528218, NSC 528218
Molecular Weight	193.68
Formula	C6H16ClN5
CAS No.	1190-53-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (309.79 mM)

References and Literature

1. Amanda B Parris, et al. Buformin hydrochloride Inhibits the Stemness of erbB-2-overexpressing Breast Cancer Cells and Premalignant Mammary Tissues of MMTV-erbB-2 Transgenic Mice. J Exp Clin Cancer Res 2. Jing Li, et al. Buformin hydrochloride Suppresses Proliferation and Invasion via AMPK/S6 Pathway in Cervical Cancer and Synergizes With Paclitaxel. Cancer Biol Ther. 2018 Jun 3;19(6):507-517. 3. Gutsche H, Blumenbach L, Losert W, Wiemann H. [Concentration of 14C-1-butylbiguanide in plasma of diabetic patients and its elimination after administration of a new Galenical formulation (author's transl)]. Arzneimittelforschung. 1976;26(6):1227-9. German. PubMed PMID: 989423. 4. Beckmann VR. [Reduction of serum triglycerides with a combined application of butylbiguanide and clofibrate in animal experiments]. Arzneimittelforschung. 1975 May;25(5):775-6. German. PubMed PMID: 1242321.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library FDA-Approved Kinase Inhibitor Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Anti-Cancer Drug Library Kinase Inhibitor Library Anti-Liver Cancer Compound Library PI3K-AKT-mTOR Compound Library Anti-Diabetic Compound Library Orally Active Compound Library

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Keywords

Buformin hydrochloride 1190-53-0 Chromatin/Epigenetic PI3K/Akt/mTOR signaling AMPK agent Type II diabete inhibit Inhibitor SKBR3 cervical cancer breast cancer biguanide analog BT474 NSC528218 NSC-528218 1-Butylbiguanide antidiabetic AMP-activated protein kinase Buformin Buformin Hydrochloride NSC 528218 inhibitor

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