Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bupivacaine hydrochloride (Vivacaine) is a long-acting, amide-type local anesthetic. Bupivacaine hydrochloride reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent membrane permeability to sodium ions and membrane stabilization; inhibition of depolarization and nerve impulse conduction; and a reversible loss of sensation.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
50 mg | In stock | $ 43.00 | |
100 mg | In stock | $ 59.00 | |
200 mg | In stock | $ 68.00 | |
500 mg | In stock | $ 89.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Bupivacaine hydrochloride (Vivacaine) is a long-acting, amide-type local anesthetic. Bupivacaine hydrochloride reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent membrane permeability to sodium ions and membrane stabilization; inhibition of depolarization and nerve impulse conduction; and a reversible loss of sensation. |
In vitro | Bupivacaine can induce calcium release from the sarcoplasmic reticulum (SR) in rats and suppress the SR's uptake of calcium. |
In vivo | In vitro, Bupivacaine exhibits cytotoxic effects on bovine articular chondrocytes after an exposure of 15 to 30 minutes. It acts on isolated mitochondria as an uncoupler of oxygen consumption and adenosine diphosphate phosphorylation. Concentration-dependent mitochondrial depolarization and pyridine nucleotide oxidation are induced by Bupivacaine in these isolated mitochondria. Additionally, Bupivacaine triggers the opening of the permeability transition pore (PTP), a cyclosporin A-sensitive inner membrane channel pivotal in various forms of cell death. |
Synonyms | Vivacaine, Bupivacaine HCl |
Molecular Weight | 324.89 |
Formula | C18H28N2O·HCl |
CAS No. | 18010-40-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/mL (184.7 mM)
H2O: 21 mg/mL (64.6 mM)
Ethanol: 60 mg/mL (184.7 mM)
You can also refer to dose conversion for different animals. More
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Bupivacaine hydrochloride 18010-40-7 Membrane transporter/Ion channel Sodium Channel Potassium Channel Inhibitor NMDA Na+ channels local inhibit Bupivacaine electrophysiology Ionotropic glutamate receptors channel Vivacaine pain Na channels iGluR Ca channels Bupivacaine HCl anesthetics Calcium Channel Bupivacaine Hydrochloride Ca2+ channels KcsA inhibitor