store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bz 423 is a potent immunomodulator that induces apoptosis by activating Bax and Bak to induce mitochondrial outer membrane permeabilization and cytochrome c release.Bz 423 shows partial activity in a mouse model of lupus.
Pack Size | Availability | Price/USD | Quantity |
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2 mg | In stock | $ 48.00 |
Description | Bz 423 is a potent immunomodulator that induces apoptosis by activating Bax and Bak to induce mitochondrial outer membrane permeabilization and cytochrome c release.Bz 423 shows partial activity in a mouse model of lupus. |
In vitro | Bz-423 triggers the activation of Bax and Bak without concurrently activating ASK1/JNK in Ramos cells[2]. The induction of apoptosis by Bz-423 in Ramos cells relies on superoxide, and it elicits a heightened superoxide response in these cells, resulting in the swift demise of Ramos B cells. In MEFs, Bz-423 rapidly elevates superoxide levels within 1 hour, with the extent of the increase depending on the concentration. In Ramos cells, Bz-423-induced superoxide generation instigates the activation of Bax and Bak, mediated by alterations in Mcl-1 expression and the functional activation of BH3-only proteins[1]. |
Synonyms | BZ48 |
Molecular Weight | 440.92 |
Formula | C27H21ClN2O2 |
CAS No. | 216691-95-1 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (181.44 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Bz 423 216691-95-1 Apoptosis BCL BZ-48 BZ48 BZ 48 inhibitor inhibit