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CAY10404

Catalog No. T8656   CAS 340267-36-9
Synonyms: Bcl-XL, CAY10404, cancer, COX, anti-inflammatory, Bcl-2, Apoptosis, Akt, H-1703, Cyclooxygenase, NSCLC, CAY 10404, H-358, inhibit, cell, 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T, pGSK-3β, H-460, analgesic, MAPK, CAY-10404, cyclooxygenase-2, lung, anti-cancer, Inhibitor, Non-small, Protein kinase B, pAkt, PKB

CAY10404 is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSCLC cells, with analgesic, anti-inflammatory and anti-cancer activities.

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CAY10404, CAS 340267-36-9
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Purity: 98%
Biological Description
Chemical Properties
Storage & Solubility Information
Description CAY10404 is a potent and highly selective inhibitor of COX-2 and COX-1. It is also a potent inhibitor of PKB/Akt and MAPK signalling pathways and induces apoptosis in NSCLC cells, with analgesic, anti-inflammatory and anti-cancer activities.
Targets&IC50 COX-2:1 nM, COX-1:>500 μM
In vitro Treatment with CAY10404 in the range of 10-100 microM caused dose-dependent growth inhibition, with an average 50% inhibitory concentration (IC(50)) of 60-100 micromol/L, depending on the cell line.?Western blot analysis of CAY10404-treated cells showed cleavage of poly (ADP-ribose) polymerase (PARP) and procaspase-3, signifying caspase activity and apoptotic cell death.?CAY10404 treatment inhibited the phosphorylation of Akt, glycogen synthase kinase-3beta and extracellular signal-regulated kinases 1/2 in H460 and H358 cells[1]
Cell Research To measure the effects of CAY10404 on proliferation of NSCLC cells, 3 x 10(3) cells/well were plated in 96-well plates and allowed to adhere overnight at 37 degrees C. After treatment with CAY10404 for 3 days, cell proliferation was measured by the 3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. In the H460 NSCLC cells, evidence of apoptosis was sought using the terminal deoxynucleotidyl transferase deoxyuridine triphosphate (dUTP) nick end labelling (TUNEL) assay and western blot analysis[1].
Synonyms Bcl-XL, CAY10404, cancer, COX, anti-inflammatory, Bcl-2, Apoptosis, Akt, H-1703, Cyclooxygenase, NSCLC, CAY 10404, H-358, inhibit, cell, 3-(4-METHYLSULPHONYLPHENYL)-4-PHENYL-5-T, pGSK-3β, H-460, analgesic, MAPK, CAY-10404, cyclooxygenase-2, lung, anti-cancer, Inhibitor, Non-small, Protein kinase B, pAkt, PKB
Molecular Weight 367.34
Formula C17H12F3NO3S
CAS No. 340267-36-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Yongseon Cho, et al. Effects of CAY10404 on the PKB/Akt and MAPK pathway and apoptosis in non-small cell lung cancer cells. Respirology. 2009 Aug;14(6):850-8. 2. Joshua A Robertson, et al. The role of cyclooxygenase-2 in mechanical ventilation-induced lung injury. Am J Respir Cell Mol Biol. 2012 Sep;47(3):387-94.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Compound Library Anti-Lung Cancer Compound Library Anti-Cardiovascular Disease Compound Library Inhibitor Library Immunology/Inflammation Compound Library Anti-Cancer Active Compound Library Kinase Inhibitor Library Nonsteroidal Anti-Inflammatory Compound Library Neuronal Signaling Compound Library Anti-Aging Compound Library

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Taspine Sprengerinin C Neogrifolin Hirsutenone Broussonin A 2,3-Dihydro-3-methoxywithaferin A DL-Syringaresinol Dehydroglyasperin D

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