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CAY10594

Catalog No. T7280 CAS 1130067-34-3

CAY10594 is a potent phospholipase D2(PLD2) inhibitor. CAY10594 ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis.

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CAY10594, CAS 1130067-34-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 76.00
5 mg	In stock	$ 163.00
10 mg	In stock	$ 278.00
25 mg	In stock	$ 497.00
50 mg	In stock	$ 723.00
100 mg	In stock	$ 987.00
1 mL * 10 mM (in DMSO)	In stock	$ 178.00

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Purity: 98%

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Description	CAY10594 is a potent phospholipase D2(PLD2) inhibitor. CAY10594 ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis.
In vivo	CAY10594 administration markedly blocked the acute liver injury in a dose-dependent manner, showing almost complete inhibition with 8?mg/kg of CAY10594. During the pathological progress of acute liver injury, GSH levels are decreased, and this is significantly recovered upon the administration of CAY10594 at 6?hours post APAP challenge. GSK-3β (Serine 9)/JNK phosphorylation is mainly involved in APAP-induced liver injury. CAY10594 administration strongly blocked GSK-3β (Serine 9)/JNK phosphorylation in the APAP-induced acute liver injury model. Consistently, sustained JNK activation in the cytosol and mitochondria from hepatocytes were also decreased in CAY10594-treated mice. Many types of immune cells are also implicated in APAP-induced liver injury. However, neutrophil and monocyte populations were not different between vehicle- and CAY10594-administered mice which are challenged with APAP. Therapeutic administration of CAY10594 also significantly attenuated liver damage caused by the APAP challenge, eliciting an enhanced survival rate[1].
Animal Research	Mice were fasted for 16?hours before APAP injection. APAP (500?mg/kg) was administered with oral gavage in mice. CAY10594 (N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,5]dec-8-yl)ethyl]-2-naphthalene carboxamide)23 was dissolved in 1% DMSO and intraperitoneally administered to mice 30?minutes prior to APAP injection for examining protective effects or after 3?hours from APAP challenge for investigating therapeutic effects of CAY10594[1].

Molecular Weight	428.53
Formula	C26H28N4O2
CAS No.	1130067-34-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 20mg/ml(46.7mM)

References and Literature

1. Lee SK, Bae GH, Kim YS,et al.A phospholipase D2 inhibitor, CAY10594, ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis[J].Sci Rep. 2019 May 10;9(1):7242. 2. Pupovac A , Stokes L , Sluyter R . CAY10593 inhibits the human P2X7 receptor independently of phospholipase D1 stimulation[J]. Purinergic Signalling, 2013, 9(4):609-619. 3. Zhang Y, Li Y, Liu P, et al. Phosphatase Shp2 regulates biogenesis of small extracellular vesicles by dephosphorylating Syntenin[J]. Journal of extracellular vesicles. 2021, 10(5): e12078.

Citations

1. Zhang Y, Li Y, Liu P, et al. Phosphatase Shp2 regulates biogenesis of small extracellular vesicles by dephosphorylating Syntenin. Journal of extracellular vesicles. 2021 Mar;10(5):e12078. doi: 10.1002/jev2.12078. Epub 2021 Mar 10. 2. Liu Z, Nan Y, Luo Q, et al. DLGAP1-AS2-Mediated Phosphatidic Acid Synthesis Activates YAP Signaling and Confers Chemoresistance in Squamous Cell Carcinoma. Cancer Research. 2022

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Cancer Active Compound Library Anti-Obesity Compound Library Anti-Metabolism Disease Compound Library NO PAINS Compound Library Metabolism Compound Library Bioactive Lipid Compound Library Anti-Cancer Compound Library Lipid Metabolism Compound Library Bioactive Compounds Library Max

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VU534 LFHP-1c BMS493 Levamisole hydrochloride Lp-PLA2-IN-2 LEI-401 Halobetasol propionate Neomycin sulfate

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Keywords

CAY10594 1130067-34-3 Metabolism Phospholipase Inhibitor CAY 10594 inhibit CAY-10594 inhibitor

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