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CCG-63802

Catalog No. T14897 CAS 620112-78-9

CCG-63802 is a reversible small-molecule inhibitor of regulator of G protein signaling (RGS) proteins. CCG-63802 inhibits the interaction between RGS4 and Galpha with an IC50 value of 1.4 μM.

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CCG-63802, CAS 620112-78-9

Pack Size	Availability	Price/USD
5 mg	In stock	$ 57.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 213.00
50 mg	In stock	$ 395.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	CCG-63802 is a reversible small-molecule inhibitor of regulator of G protein signaling (RGS) proteins. CCG-63802 inhibits the interaction between RGS4 and Galpha with an IC50 value of 1.4 μM.
Targets&IC50	RGS4:1.4 μM
In vitro	CCG-63802 inhibits GTPase accelerating protein activity of RGS4 and blocks its interaction with Gαo.

Molecular Weight	450.51
Formula	C26H18N4O2S
CAS No.	620112-78-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 1.67 mg/mL (3.71 mM), Sonification and heating are recommended.

References and Literature

1. Blazer LL, et al. Reversible, allosteric small-molecule inhibitors of regulator of G protein signaling proteins. Mol Pharmacol. 2010 Sep;78(3):524-33. 2. Meng X, et al. PPARγ Agonist PGZ Attenuates OVA-Induced Airway Inflammation and Airway Remodeling via RGS4 Signaling in Mouse Model. Inflammation. 2018 Jul 19. 3. Bosier B, et al. Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling. Br J Pharmacol. 2015 Nov;172(22):5333-46.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Inhibitor Library Bioactive Compound Library PPI Inhibitor Library Bioactive Compounds Library Max Covalent Inhibitor Library Anti-Cancer Compound Library

Related Products

Related compounds with same targets

CCG-63808 BQU57 RBC10 RBC8 Exo-1 NAV-2729 CCG 203769 Compound C108

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CCG-63802 620112-78-9 GPCR/G Protein GTPase inflammation CCG 63802 RGS reversible selective Regulator of G-protein Signaling Regulators of G-protein Signaling inhibit CCG63802 Inhibitor RGS Protein inhibitor

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