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CCR4 antagonist 2

Catalog No. T10713   CAS 2206788-99-8

CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively.

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CCR4 antagonist 2 Chemical Structure
CCR4 antagonist 2, CAS 2206788-99-8
Pack Size Availability Price/USD Quantity
25 mg 10-14 weeks $ 2,720.00
50 mg 10-14 weeks $ 3,580.00
100 mg 10-14 weeks $ 4,900.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively.
Targets&IC50 CTX,CCR4 antagonist 2:70 nM , Ca2+flux:40 nM
Molecular Weight 511.45
Formula C26H28Cl2N6O
CAS No. 2206788-99-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Jackson JJ, et al. Discovery of a Potent and Selective CCR4 Antagonist That Inhibits Treg Trafficking into the Tumor Microenvironment. J Med Chem. 2019 Jul 11;62(13):6190-6213.

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Keywords

CCR4 antagonist 2 2206788-99-8 Membrane transporter/Ion channel Metabolism Calcium Channel CCR-4 antagonist 2 inhibitor inhibit

 

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