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CEP-28122

Catalog No. T2612 CAS 1022958-60-6

CEP-28122 is a highly potent and selective orally active ALK inhibitor.

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CEP-28122, CAS 1022958-60-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 50.00
2 mg	In stock	$ 75.00
5 mg	In stock	$ 135.00
10 mg	In stock	$ 219.00
25 mg	4-6 weeks	$ 395.00

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Purity: 100%

Biological Description

Chemical Properties

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Description	CEP-28122 is a highly potent and selective orally active ALK inhibitor.
Targets&IC50	ALK:1.9 ± 0.5 nM
Kinase Assay	Flashplate assay for identification and evaluation of Aurora inhibitors: On this assay 384-well Basic Flashplate? as solid assay platform is used. The plates are coated overnight at 4 °C with dithiothreitol (DTT) at 100 μg/mL in PBS buffer and used after being washed twice with PBS. 5 μL of CCT137690 in 2% DMSO is added to each well followed by 15 μL master mix of kinase buffer (50 mM Tris pH 7.5, 10 mM NaCl, 2.5 mM MgCl2, 1 mM myelin basic protein (MBP), 20 μM ATP, and 0.025 μCi/μL 33P-ATP). Finally, 250 ng per well of Aurora-A enzyme is added. The plate is shaken for approximately 2 min on a flat-bed plate shaker and incubated for 2 hours at room temperature. The reaction is stopped by washing the plate twice on a 16-pin wash with 10 mM sodium pyrophosphate. The plate is then read on a TopCount-NXTTM. For the determination of the inhibitory activity against Aurora-B or Aurora-C, the same conditions are followed in the assay using Aurora-B or Aurora-C enzymes.

Molecular Weight	539.07
Formula	C28H35ClN6O3
CAS No.	1022958-60-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mM

References and Literature

1. Abate F, et al. Leukemia. 2015 Jun;29(6):1390-401.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CEP-28122 1022958-60-6 Angiogenesis Tyrosine Kinase/Adaptors ALK CEP 28122 Anaplastic lymphoma kinase (ALK) Anaplastic lymphoma kinase CEP28122 CD246 Inhibitor ALK tyrosine kinase receptor Cluster of differentiation 246 inhibit inhibitor

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