Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CEP-28122 mesylate salt (1022958-60-6 free base) is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 66.00 | |
2 mg | In stock | $ 94.00 | |
5 mg | In stock | $ 135.00 | |
10 mg | In stock | $ 205.00 | |
25 mg | In stock | $ 369.00 | |
50 mg | In stock | $ 487.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 216.00 |
Description | CEP-28122 mesylate salt (1022958-60-6 free base) is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay). |
Targets&IC50 | ALK:1.9 nM |
In vitro | CEP-28122 is a potent inhibitor of recombinant ALK activity and cellular ALK tyrosine phosphorylation. CEP-28122 also inhibits Flt4 (IC50: 46 nM). CEP-28122 induces concentration-dependent growth inhibition/cytotoxicity of ALK-positive anaplastic large-cell lymphoma (ALCL), neuroblastoma cells, and non-small cell lung cancer (NSCLC). |
In vivo | CEP-28122 displays dose-dependent inhibition of ALK tyrosine phosphorylation in tumor xenografts in mice, with substantial target inhibition (>90%) for more than12 hours following single oral dosing at 30 mg/kg. Dose-dependent antitumor activity was observed in ALK-positive ALCL, NSCLC, and neuroblastoma tumor xenografts in mice administered CEP-28122 orally, with complete/near-complete tumor regressions observed following treatment at doses of 30 mg/kg twice daily or higher. |
Synonyms | CEP-28122 mesylate salt |
Molecular Weight | 635.17 |
Formula | C29H39ClN6O6S |
CAS No. | T10759 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6.4 mg/mL (10.08 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CEP-28122 mesylate salt (1022958-60-6 free base) T10759 Angiogenesis Tyrosine Kinase/Adaptors ALK CEP 28122 mesylate salt (1022958 60 6 free base) 1022958-60-6 CEP 28122 Mesylate CEP28122 mesylate salt (1022958606 free base) CEP-28122 Mesylate CEP-28122 mesylate salt 1022958-60-6 free base CEP28122 Mesylate inhibitor inhibit