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CH5132799

Catalog No. T2619   CAS 1007207-67-1

CH5132799 has been used in trials studying the treatment of Solid Tumors.

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CH5132799 Chemical Structure
CH5132799, CAS 1007207-67-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 58.00
2 mg In stock $ 88.00
5 mg In stock $ 147.00
10 mg In stock $ 239.00
25 mg In stock $ 443.00
50 mg In stock $ 655.00
100 mg In stock $ 932.00
500 mg In stock $ 1,880.00
1 mL * 10 mM (in DMSO) In stock $ 162.00
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Purity: 99.87%
Purity: 98.81%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description CH5132799 has been used in trials studying the treatment of Solid Tumors.
Targets&IC50 PI3Kγ:36 nM, PI3Kα:14 nM, PI3Kβ:0.12 μM, PI3Kδ:0.50 μM
Kinase Assay PI3K Assay: The E542K, E545K, and H1047R mutants of PI3Kα are prepared with an overlapped extension-polymerase chain reaction. Glutathione S-transferase-tagged PI3Kα mutants and His-tagged p85α are co-expressed with BAC-TO-BAC Baculovirus Expression System. The inhibitory activities of CH5132799 on PI3Kα (p110α/p85α), PI3Kβ(p110β/p85α), PI3Kδ (p110δ/p85α), PI3Kγ (p110γ), PI3KC2α, PI3KC2β, Vps34, and PI3Kα mutants are determined by Adapta Universal Kinase Assay Kit. Time-resolved fluorescence is measured with an EnVision HTS microplate reader. IC50 values are calculated using XLfit.
Cell Research The cell lines are added to the wells of 96-well plates containing 0.076 to 10,000 nM CH5132799 and incubated at 37 °C. After 4 days of incubation, Cell Counting Kit-8 solution is added and, after incubation for several more hours, absorbance at 450 nm is measured with Microplate-Reader iMark. The antiproliferative activity is calculated by the formula (1- T/C) × 100 (%), in which T and C represent absorbance at 450 nm of the cells treated with CH5132799 (T) and that of untreated control cells (C). The IC50 values are calculated by using Microsoft Excel 2007. (Only for Reference)
Molecular Weight 377.42
Formula C15H19N7O3S
CAS No. 1007207-67-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 10 mg/mL (26.5 mM)

TargetMolReferences and Literature

1. Tanaka H, et al, Clin Cancer Res, 2011, 17(10), 3272-3281. 2. Ohwada J, et al, Bioorg Med Chem Leff, 2011, 21(6), 1767-1772.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Aging Compound Library Anti-Metabolism Disease Compound Library NO PAINS Compound Library Anti-Liver Cancer Compound Library Anti-Ovarian Cancer Compound Library HIF-1 Signaling Pathway Compound Library Antidepressant Compound Library

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mTOR inhibitor 13 Palomid 529 ETP-46464 CCT128930 hydrochloride mTOR inhibitor-11 mTOR inhibitor-3 GNE-493 Temsirolimus

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Keywords

CH5132799 1007207-67-1 PI3K/Akt/mTOR signaling PI3K mTOR Phosphoinositide 3-kinase Inhibitor CH-5132799 CH 5132799 inhibit inhibitor

 

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