Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CH5132799 has been used in trials studying the treatment of Solid Tumors.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 58.00 | |
2 mg | In stock | $ 88.00 | |
5 mg | In stock | $ 147.00 | |
10 mg | In stock | $ 239.00 | |
25 mg | In stock | $ 443.00 | |
50 mg | In stock | $ 655.00 | |
100 mg | In stock | $ 932.00 | |
500 mg | In stock | $ 1,880.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 162.00 |
Description | CH5132799 has been used in trials studying the treatment of Solid Tumors. |
Targets&IC50 | PI3Kγ:36 nM, PI3Kα:14 nM, PI3Kβ:0.12 μM, PI3Kδ:0.50 μM |
Kinase Assay | PI3K Assay: The E542K, E545K, and H1047R mutants of PI3Kα are prepared with an overlapped extension-polymerase chain reaction. Glutathione S-transferase-tagged PI3Kα mutants and His-tagged p85α are co-expressed with BAC-TO-BAC Baculovirus Expression System. The inhibitory activities of CH5132799 on PI3Kα (p110α/p85α), PI3Kβ(p110β/p85α), PI3Kδ (p110δ/p85α), PI3Kγ (p110γ), PI3KC2α, PI3KC2β, Vps34, and PI3Kα mutants are determined by Adapta Universal Kinase Assay Kit. Time-resolved fluorescence is measured with an EnVision HTS microplate reader. IC50 values are calculated using XLfit. |
Cell Research | The cell lines are added to the wells of 96-well plates containing 0.076 to 10,000 nM CH5132799 and incubated at 37 °C. After 4 days of incubation, Cell Counting Kit-8 solution is added and, after incubation for several more hours, absorbance at 450 nm is measured with Microplate-Reader iMark. The antiproliferative activity is calculated by the formula (1- T/C) × 100 (%), in which T and C represent absorbance at 450 nm of the cells treated with CH5132799 (T) and that of untreated control cells (C). The IC50 values are calculated by using Microsoft Excel 2007. (Only for Reference) |
Molecular Weight | 377.42 |
Formula | C15H19N7O3S |
CAS No. | 1007207-67-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 10 mg/mL (26.5 mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CH5132799 1007207-67-1 PI3K/Akt/mTOR signaling PI3K mTOR Phosphoinositide 3-kinase Inhibitor CH-5132799 CH 5132799 inhibit inhibitor