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CHM-1

Catalog No. T22661 CAS 154554-41-3

CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo.

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CHM-1, CAS 154554-41-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 55.00
2 mg	In stock	$ 81.00
5 mg	In stock	$ 133.00
10 mg	In stock	$ 222.00
25 mg	In stock	$ 478.00
50 mg	In stock	$ 686.00
100 mg	In stock	$ 997.00
500 mg	In stock	$ 1,990.00

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Purity: 100%

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Description	CHM-1 is an inducer of apoptosis, and displays potent antitumor ability in human hepatocellular carcinoma by activation of Cdc2 kinase activity. CHM-1 inhibits tubulin polymerization in vitro and in vivo.
Targets&IC50	Apoptosis:0.75 μM (HA22T)
In vitro	CHM-1 (0-10 μM; 24 hours) significantly increased the binding of cyclin B1 to Cdc2 and induced change in expressed and phosphorylated status of G2-M regulators in HA22T cells. CHM-1 (0-100μM; 24 hours) induced significant concentration-dependent growth inhibition in HA22T, Hep3B, and HepG2 cells, with the most potent effects observed in HA22T cells with an IC50 of 0.75 μM)[3].
In vivo	In male severe combined immunodeficient mice, CHM-1 (10 mg/kg; i.p.) induced inhibition of HA22T tumor growth in a dose-dependent manner[3].

Molecular Weight	283.25
Formula	C16H10FNO3
CAS No.	154554-41-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: < 7.08 mg/mL

References and Literature

1. Liu CW, et al. CHM-1, a novel microtubule-destabilizing agent exhibits antitumor activity via inducing the expression of SIRT2 in human breast cancer cells. Chem Biol Interact. 2018 Jun 1;289:98-108. 2. Tsai AC, et al. CHM-1, a new vascular targeting agent, induces apoptosis of human umbilical vein endothelial cells via p53-mediated death receptor 5 up-regulation. J Biol Chem. 2010 Feb 19;285(8):5497-506. 3. Wang SW, et al. CHM-1, a novel synthetic quinolone with potent and selective antimitotic antitumor activity against human hepatocellular carcinoma in vitro and in vivo. Mol Cancer Ther. 2008 Feb;7(2):350-60.

Related compound libraries

This product is contained In the following compound libraries：

Microtubule-Targeted Compound Library Anti-Cancer Active Compound Library Inhibitor Library Anti-Cancer Compound Library Bioactive Compound Library Bioactive Compounds Library Max Cytoskeletal Signaling Pathway Compound Library

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Keywords

CHM-1 154554-41-3 Apoptosis Cytoskeletal Signaling Others Microtubule Associated Inhibitor microtubule-destabilizing Cdc2 carcinoma NSC-656158 Microtubule/Tubulin hepatocellular NSC656158 antitumor inhibit CHM1 antimitotic CHM 1 NSC 656158 inhibitor

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